In vivo spatial correlation between 18F-BPA and 18F-FDG uptakes in head and neck cancer

Kazuma Kobayashi; Hiroaki Kurihara; Yoshiaki Watanabe; Naoya Murakami; Koji Inaba; Satoshi Nakamura; Akihisa Wakita; Hiroyuki Okamoto; Rei Umezawa; Kana Takahashi; Hiroshi Igaki; Yoshinori Ito; Seiichi Yoshimoto; Naoyuki Shigematsu; Jun Itami

doi:10.1016/j.apradiso.2016.05.026

In vivo spatial correlation between ¹⁸F-BPA and ¹⁸F-FDG uptakes in head and neck cancer

Kazuma Kobayashi, Hiroaki Kurihara, Yoshiaki Watanabe, Naoya Murakami, Koji Inaba, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Rei Umezawa, Kana Takahashi, Hiroshi Igaki, Yoshinori Ito, Seiichi Yoshimoto, Naoyuki Shigematsu, Jun Itami

Department of Radiology (Radiation Oncology)

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background and purpose Borono-2-¹⁸F-fluoro-phenylalanine (¹⁸F-BPA) has been used to estimate the therapeutic effects of boron neutron capture therapy (BNCT), while ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) is the most commonly used positron emission tomography (PET) radiopharmaceutical in a routine clinical use. The aim of the present study was to evaluate spatial correlation between ¹⁸F-BPA and ¹⁸F-FDG uptakes using a deformable image registration-based technique. Material and methods Ten patients with head and neck cancer were recruited from January 2014 to December 2014. All patients underwent whole-body ¹⁸F-BPA PET/computed tomography (CT) and ¹⁸F-FDG PET/CT within a 2-week period. For each patient, ¹⁸F-BPA PET/CT and ¹⁸F-FDG PET/CT images were aligned based on a deformable image registration framework. The voxel-by-voxel spatial correlation of standardized uptake value (SUV) within the tumor was analyzed. Results Our image processing framework achieved accurate and validated registration results for each PET/CT image. In 9/10 patients, the spatial distribution of SUVs between ¹⁸F-BPA and ¹⁸F-FDG showed a significant, positive correlation in the tumor volume. Conclusions Deformable image registration-based voxel-wise analysis demonstrated a spatial correlation between ¹⁸F-BPA and ¹⁸F-FDG uptakes in the head and neck cancer. A tumor sub-volume with a high ¹⁸F-FDG uptake may predict high accumulation of ¹⁸F-BPA.

Original language	English
Pages (from-to)	138-146
Number of pages	9
Journal	Applied Radiation and Isotopes
Volume	115
DOIs	https://doi.org/10.1016/j.apradiso.2016.05.026
Publication status	Published - 2016 Sep 1

Keywords

BNCT
BPA
Deformable registration
FDG
Head and neck cancer
PET/CT

ASJC Scopus subject areas

Radiation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.apradiso.2016.05.026

Cite this

Kobayashi, K., Kurihara, H., Watanabe, Y., Murakami, N., Inaba, K., Nakamura, S., Wakita, A., Okamoto, H., Umezawa, R., Takahashi, K., Igaki, H., Ito, Y., Yoshimoto, S., Shigematsu, N., & Itami, J. (2016). In vivo spatial correlation between ¹⁸F-BPA and ¹⁸F-FDG uptakes in head and neck cancer. Applied Radiation and Isotopes, 115, 138-146. https://doi.org/10.1016/j.apradiso.2016.05.026

Kobayashi, K, Kurihara, H, Watanabe, Y, Murakami, N, Inaba, K, Nakamura, S, Wakita, A, Okamoto, H, Umezawa, R, Takahashi, K, Igaki, H, Ito, Y, Yoshimoto, S, Shigematsu, N & Itami, J 2016, 'In vivo spatial correlation between ¹⁸F-BPA and ¹⁸F-FDG uptakes in head and neck cancer', Applied Radiation and Isotopes, vol. 115, pp. 138-146. https://doi.org/10.1016/j.apradiso.2016.05.026

@article{44511d85df434f81ba033376ce7bc959,

title = "In vivo spatial correlation between 18F-BPA and 18F-FDG uptakes in head and neck cancer",

abstract = "Background and purpose Borono-2-18F-fluoro-phenylalanine (18F-BPA) has been used to estimate the therapeutic effects of boron neutron capture therapy (BNCT), while 18F-fluorodeoxyglucose (18F-FDG) is the most commonly used positron emission tomography (PET) radiopharmaceutical in a routine clinical use. The aim of the present study was to evaluate spatial correlation between 18F-BPA and 18F-FDG uptakes using a deformable image registration-based technique. Material and methods Ten patients with head and neck cancer were recruited from January 2014 to December 2014. All patients underwent whole-body 18F-BPA PET/computed tomography (CT) and 18F-FDG PET/CT within a 2-week period. For each patient, 18F-BPA PET/CT and 18F-FDG PET/CT images were aligned based on a deformable image registration framework. The voxel-by-voxel spatial correlation of standardized uptake value (SUV) within the tumor was analyzed. Results Our image processing framework achieved accurate and validated registration results for each PET/CT image. In 9/10 patients, the spatial distribution of SUVs between 18F-BPA and 18F-FDG showed a significant, positive correlation in the tumor volume. Conclusions Deformable image registration-based voxel-wise analysis demonstrated a spatial correlation between 18F-BPA and 18F-FDG uptakes in the head and neck cancer. A tumor sub-volume with a high 18F-FDG uptake may predict high accumulation of 18F-BPA.",

keywords = "BNCT, BPA, Deformable registration, FDG, Head and neck cancer, PET/CT",

author = "Kazuma Kobayashi and Hiroaki Kurihara and Yoshiaki Watanabe and Naoya Murakami and Koji Inaba and Satoshi Nakamura and Akihisa Wakita and Hiroyuki Okamoto and Rei Umezawa and Kana Takahashi and Hiroshi Igaki and Yoshinori Ito and Seiichi Yoshimoto and Naoyuki Shigematsu and Jun Itami",

note = "Funding Information: This work has been financially supported by Grants-in-Aid for Young Scientists (B) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (Grant number 15K19837 ); Health and Labor Sciences Research Grants for Commission (H26-applied-general-036); and the Practical Research for Innovative Cancer Control from Japan Agency for Medical Research and development, AMED. Publisher Copyright: {\textcopyright} 2016 The Authors",

year = "2016",

month = sep,

day = "1",

doi = "10.1016/j.apradiso.2016.05.026",

language = "English",

volume = "115",

pages = "138--146",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - In vivo spatial correlation between 18F-BPA and 18F-FDG uptakes in head and neck cancer

AU - Kobayashi, Kazuma

AU - Kurihara, Hiroaki

AU - Watanabe, Yoshiaki

AU - Murakami, Naoya

AU - Inaba, Koji

AU - Nakamura, Satoshi

AU - Wakita, Akihisa

AU - Okamoto, Hiroyuki

AU - Umezawa, Rei

AU - Takahashi, Kana

AU - Igaki, Hiroshi

AU - Ito, Yoshinori

AU - Yoshimoto, Seiichi

AU - Shigematsu, Naoyuki

AU - Itami, Jun

N1 - Funding Information: This work has been financially supported by Grants-in-Aid for Young Scientists (B) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (Grant number 15K19837 ); Health and Labor Sciences Research Grants for Commission (H26-applied-general-036); and the Practical Research for Innovative Cancer Control from Japan Agency for Medical Research and development, AMED. Publisher Copyright: © 2016 The Authors

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background and purpose Borono-2-18F-fluoro-phenylalanine (18F-BPA) has been used to estimate the therapeutic effects of boron neutron capture therapy (BNCT), while 18F-fluorodeoxyglucose (18F-FDG) is the most commonly used positron emission tomography (PET) radiopharmaceutical in a routine clinical use. The aim of the present study was to evaluate spatial correlation between 18F-BPA and 18F-FDG uptakes using a deformable image registration-based technique. Material and methods Ten patients with head and neck cancer were recruited from January 2014 to December 2014. All patients underwent whole-body 18F-BPA PET/computed tomography (CT) and 18F-FDG PET/CT within a 2-week period. For each patient, 18F-BPA PET/CT and 18F-FDG PET/CT images were aligned based on a deformable image registration framework. The voxel-by-voxel spatial correlation of standardized uptake value (SUV) within the tumor was analyzed. Results Our image processing framework achieved accurate and validated registration results for each PET/CT image. In 9/10 patients, the spatial distribution of SUVs between 18F-BPA and 18F-FDG showed a significant, positive correlation in the tumor volume. Conclusions Deformable image registration-based voxel-wise analysis demonstrated a spatial correlation between 18F-BPA and 18F-FDG uptakes in the head and neck cancer. A tumor sub-volume with a high 18F-FDG uptake may predict high accumulation of 18F-BPA.

AB - Background and purpose Borono-2-18F-fluoro-phenylalanine (18F-BPA) has been used to estimate the therapeutic effects of boron neutron capture therapy (BNCT), while 18F-fluorodeoxyglucose (18F-FDG) is the most commonly used positron emission tomography (PET) radiopharmaceutical in a routine clinical use. The aim of the present study was to evaluate spatial correlation between 18F-BPA and 18F-FDG uptakes using a deformable image registration-based technique. Material and methods Ten patients with head and neck cancer were recruited from January 2014 to December 2014. All patients underwent whole-body 18F-BPA PET/computed tomography (CT) and 18F-FDG PET/CT within a 2-week period. For each patient, 18F-BPA PET/CT and 18F-FDG PET/CT images were aligned based on a deformable image registration framework. The voxel-by-voxel spatial correlation of standardized uptake value (SUV) within the tumor was analyzed. Results Our image processing framework achieved accurate and validated registration results for each PET/CT image. In 9/10 patients, the spatial distribution of SUVs between 18F-BPA and 18F-FDG showed a significant, positive correlation in the tumor volume. Conclusions Deformable image registration-based voxel-wise analysis demonstrated a spatial correlation between 18F-BPA and 18F-FDG uptakes in the head and neck cancer. A tumor sub-volume with a high 18F-FDG uptake may predict high accumulation of 18F-BPA.

KW - BNCT

KW - BPA

KW - Deformable registration

KW - FDG

KW - Head and neck cancer

KW - PET/CT

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