In vivo spatial correlation between 18F-BPA and 18F-FDG uptakes in head and neck cancer

Kazuma Kobayashi, Hiroaki Kurihara, Yoshiaki Watanabe, Naoya Murakami, Koji Inaba, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Rei Umezawa, Kana Takahashi, Hiroshi Igaki, Yoshinori Ito, Seiichi Yoshimoto, Naoyuki Shigematsu, Jun Itami

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background and purpose Borono-2-18F-fluoro-phenylalanine (18F-BPA) has been used to estimate the therapeutic effects of boron neutron capture therapy (BNCT), while 18F-fluorodeoxyglucose (18F-FDG) is the most commonly used positron emission tomography (PET) radiopharmaceutical in a routine clinical use. The aim of the present study was to evaluate spatial correlation between 18F-BPA and 18F-FDG uptakes using a deformable image registration-based technique. Material and methods Ten patients with head and neck cancer were recruited from January 2014 to December 2014. All patients underwent whole-body 18F-BPA PET/computed tomography (CT) and 18F-FDG PET/CT within a 2-week period. For each patient, 18F-BPA PET/CT and 18F-FDG PET/CT images were aligned based on a deformable image registration framework. The voxel-by-voxel spatial correlation of standardized uptake value (SUV) within the tumor was analyzed. Results Our image processing framework achieved accurate and validated registration results for each PET/CT image. In 9/10 patients, the spatial distribution of SUVs between 18F-BPA and 18F-FDG showed a significant, positive correlation in the tumor volume. Conclusions Deformable image registration-based voxel-wise analysis demonstrated a spatial correlation between 18F-BPA and 18F-FDG uptakes in the head and neck cancer. A tumor sub-volume with a high 18F-FDG uptake may predict high accumulation of 18F-BPA.

Original languageEnglish
Pages (from-to)138-146
Number of pages9
JournalApplied Radiation and Isotopes
Publication statusPublished - 2016 Sep 1


  • BNCT
  • BPA
  • Deformable registration
  • FDG
  • Head and neck cancer
  • PET/CT

ASJC Scopus subject areas

  • Radiation


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