Inactivation of nontuberculous mycobacteria by gaseous ozone treatment

Kana Misawa, Tomoyasu Nishimura, Shoko Kashimura, Naoki Hasegawa

Research output: Contribution to journalArticlepeer-review


Nontuberculous mycobacteria (NTM) are environmental bacteria resistant to many common disinfectants and ultraviolet radiation. Inhalation of aerosols generated from NTM-containing water and soil causes NTM lung disease, especially in people with underlying lung diseases and decreased immunity. To prevent healthcare-acquired NTM infections, it is important to eradicate NTM living in hospital environments. Therefore, we evaluated the efficacy of gaseous ozone for the inactivation of NTM, namely Mycobacterium (M.) avium, M. intracellulare, M. kansasii, M. abscessus subsp. abscessus and M. abscessus subsp. massiliense. Gaseous ozone treatment at 1 ppm for 3 h reduced the bacterial number of all strains by more than 97%. Gaseous ozone treatment could be a practical, effective and convenient disinfection method for NTM living in hospital environments.

Original languageEnglish
Pages (from-to)628-630
Number of pages3
JournalJournal of Infection and Chemotherapy
Issue number6
Publication statusPublished - 2023 Jun


  • Disinfection
  • Gaseous ozone
  • Nontuberculous mycobacteria

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases


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