Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients

Makoto Naganuma, Toshimitsu Fujii, Reiko Kunisaki, Naoki Yoshimura, Masakazu Takazoe, Yoshiaki Takeuchi, Eiko Saito, Masakazu Nagahori, Keiko Asakura, Toru Takebayashi, Mamoru Watanabe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: In 2009, influenza A (H1N1) infections spread worldwide. Because the use of immunomodulators is associated with an increased risk of infection, inflammatory bowel disease (IBD) patients who are on immunomodulators might be concerned about H1N1 influenza infections. The aim of this study was to investigate the age distribution and risk factors associated with H1N1 influenza of IBD patients in 2009-2010. Methods: A multicenter, prospective study was conducted, and 570 IBD patients were enrolled. Patients were followed up for 10. months to identify any new infections. The incidence and age distribution of the H1N1 influenza infections were analyzed. IBD patients with H1N1 influenza infections and 2 matched, noninfected IBD patients were selected to assess the effect of specifying the medication on the incidence of infections. Results: A total of 38 patients (6.7%) developed H1N1 influenza infections. The incidence of H1N1 influenza infections in patients aged less than 20. years was significantly higher than that among patients in other age groups (p < 0.01). The age distribution for H1N1 influenza infections in IBD patients was comparable to those in the general population. No patients needed hospitalization due to influenza infection. A total of 29 patients (76%) recovered from the H1N1 influenza symptoms within 7. days and 20 patients (53%) received antiviral treatment. The percentage of patients who used steroids or thiopurine was comparable between the cases of H1N1 influenza infection and the control group. Conclusion: Our prospective study showed that younger IBD patients were frequently infected with the influenza A (H1N1) virus as well as general population. Admission and fatal cases due to H1N1 influenza infections were not observed.

Original languageEnglish
Pages (from-to)308-313
Number of pages6
JournalJournal of Crohn's and Colitis
Volume7
Issue number4
DOIs
Publication statusPublished - 2013 May 1

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Inflammatory Bowel Diseases
Human Influenza
Incidence
Infection
Age Distribution
Immunologic Factors
Prospective Studies
H1N1 Subtype Influenza A Virus
Age Factors
Influenza A virus
Infection Control
Population
Multicenter Studies
Antiviral Agents
Hospitalization
Age Groups
Steroids

Keywords

  • Immunomodulators
  • Inflammatory bowel disease
  • Influenza A (H1N1)
  • Steroids

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients. / Naganuma, Makoto; Fujii, Toshimitsu; Kunisaki, Reiko; Yoshimura, Naoki; Takazoe, Masakazu; Takeuchi, Yoshiaki; Saito, Eiko; Nagahori, Masakazu; Asakura, Keiko; Takebayashi, Toru; Watanabe, Mamoru.

In: Journal of Crohn's and Colitis, Vol. 7, No. 4, 01.05.2013, p. 308-313.

Research output: Contribution to journalArticle

Naganuma, M, Fujii, T, Kunisaki, R, Yoshimura, N, Takazoe, M, Takeuchi, Y, Saito, E, Nagahori, M, Asakura, K, Takebayashi, T & Watanabe, M 2013, 'Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients', Journal of Crohn's and Colitis, vol. 7, no. 4, pp. 308-313. https://doi.org/10.1016/j.crohns.2012.06.019
Naganuma, Makoto ; Fujii, Toshimitsu ; Kunisaki, Reiko ; Yoshimura, Naoki ; Takazoe, Masakazu ; Takeuchi, Yoshiaki ; Saito, Eiko ; Nagahori, Masakazu ; Asakura, Keiko ; Takebayashi, Toru ; Watanabe, Mamoru. / Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients. In: Journal of Crohn's and Colitis. 2013 ; Vol. 7, No. 4. pp. 308-313.
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AU - Naganuma, Makoto

AU - Fujii, Toshimitsu

AU - Kunisaki, Reiko

AU - Yoshimura, Naoki

AU - Takazoe, Masakazu

AU - Takeuchi, Yoshiaki

AU - Saito, Eiko

AU - Nagahori, Masakazu

AU - Asakura, Keiko

AU - Takebayashi, Toru

AU - Watanabe, Mamoru

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