Incidence and mortality pattern of malignancy and factors affecting the risk of malignancy in dialysis patients

H. Inamoto, R. Ozaki, T. Matsuzaki, Masatoshi Wakui, T. Saruta, A. Osawa

Research output: Contribution to journalArticle

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Abstract

A questionnaire study was performed among 23,209 dialysis patients in 589 institutions together with a retrospective study at Keio University Hospital to determine the risk of malignancy and factors affecting the risk ratio in dialysis patients. The incidence and mortality were 1.4-fold and 1.9-fold higher in dialysis patients than the expected rates in the general population. Incidence and mortality were 1.9-fold and 2.6-fold higher in males than in females. The risk ratios were remarkably high in university hospitals, followed by public hospitals. However, there was no significant difference between those in private hospitals and in the general population. The incidence was very high during the first 6 months of dialysis treatment and rather low in the 7th-10th year. The risk ratio of malignancy was higher in younger patients. Beyond the age of 60, the influence of age was greater than that of renal failure. Malignancies of the digestive organs were frequent and constituted 56% of all malignancies. Frequencies of malignancy in the liver, colon, rectum, bladder and kidney were higher than expected, whereas in the pancreas the frequency was lower than expected. Metastasis of malignancy was observed in 30% of the cases. Our study demonstrated a slight to moderate overall increase in the risk of malignancy and a widely differing risk ratio of malignancy by organ involved, sex, age, hospital group, epidemiological index and length of dialysis treatment in a large single racial population of maintenance dialysis patients.

Original languageEnglish
Pages (from-to)611-617
Number of pages7
JournalNephron
Volume59
Issue number4
Publication statusPublished - 1991

Fingerprint

Dialysis
Mortality
Incidence
Neoplasms
Odds Ratio
Population
Private Hospitals
Public Hospitals
Rectum
Renal Insufficiency
Pancreas
Colon
Urinary Bladder
Retrospective Studies
Age Groups
Maintenance
Neoplasm Metastasis
Kidney
Liver
Therapeutics

Keywords

  • Incidence of malignancy
  • Mortality of malignancy
  • Risk factors for malignancy
  • Risk of malignancy

ASJC Scopus subject areas

  • Nephrology

Cite this

Inamoto, H., Ozaki, R., Matsuzaki, T., Wakui, M., Saruta, T., & Osawa, A. (1991). Incidence and mortality pattern of malignancy and factors affecting the risk of malignancy in dialysis patients. Nephron, 59(4), 611-617.

Incidence and mortality pattern of malignancy and factors affecting the risk of malignancy in dialysis patients. / Inamoto, H.; Ozaki, R.; Matsuzaki, T.; Wakui, Masatoshi; Saruta, T.; Osawa, A.

In: Nephron, Vol. 59, No. 4, 1991, p. 611-617.

Research output: Contribution to journalArticle

Inamoto, H, Ozaki, R, Matsuzaki, T, Wakui, M, Saruta, T & Osawa, A 1991, 'Incidence and mortality pattern of malignancy and factors affecting the risk of malignancy in dialysis patients', Nephron, vol. 59, no. 4, pp. 611-617.
Inamoto, H. ; Ozaki, R. ; Matsuzaki, T. ; Wakui, Masatoshi ; Saruta, T. ; Osawa, A. / Incidence and mortality pattern of malignancy and factors affecting the risk of malignancy in dialysis patients. In: Nephron. 1991 ; Vol. 59, No. 4. pp. 611-617.
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