Incidence and the risk factors of spinal deformity in adult patient after spinal cord injury: a single center cohort study

Mitsuru Yagi, Atsushi Hasegawa, Masakazu Takemitsu, Yoshiyuki Yato, Masafumi Machida, Takashi Asazuma

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Study design: A retrospective consecutive case series of adult spinal cord injuries (SCIs) patients. Objective: To assess the incidence and risk factors of spinal deformity in a large sample of patients with SCIs. Summary of background data: Post-traumatic spinal deformities are well-recognized sequelae of SCIs. Despite the devastating complications for SCI patients with trunk imbalance, the incidence, clinical outcomes, and independent risk factors of scoliosis after SCI remain controversial. Materials and methods: We assessed 214 consecutive adult compressive SCI patients who were hospitalized in our hospital. We compared patients who developed spinal deformities with those who did not. Univariate and multivariate analyses to determine the independent risk factors were performed. Age, gender, etiology, ASIA grade (American Spinal Injury Association) surgery, and other demographic data were analyzed to determine the risk factors for developing a spinal deformity. Results: The average patient age was 58.3 years (20–86 years). The etiology was trauma (n = 158), ossification of ligament (n = 22), infectious (n = 17), and others. One hundred fifty-two patients had cervical spine involved, 62 had thoracic spine involved. 26 patients classified as ASIA A, 54 were ASIA B, 96 were ASIA C, and 42 were ASIA D 4. One hundred thirty-five patients had either decompression or decompression and fusion surgery. The incidence of spinal deformities was 21 % (44/214). The mean Cobb angle was 28.9 degrees (13–38°). ASIA grade and surgery predicted the occurrence of spinal deformity in both the univariate model (ASIA grade, OR: 1.59 [95 % CI: 1.04–2.44; P = 0.032]; Surgery, OR: 4.47 [95 % CI: 1.89–10.06; P = 0.0007]) and the multivariate model (ASIA grade, OR: 1.63 [95 % CI: 1.04–2.57; P = 0.033]; Surgery, OR: 4.59 [95 % CI: 1.91–11.04; P = 0.0006]), whereas surgery was the most important risk factor in the Cox model (HR: 3.50 [95 % CI: 1.56–7.88; P = 0.0025]). Conclusions: The SCI patients with high ASIA grades and those who had undergone surgery had a higher likelihood of developing a spinal deformity. Of these risk factors, surgery was the stronger risk factor.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalEuropean Spine Journal
Volume24
Issue number1
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Spinal Cord Injuries
Cohort Studies
Incidence
Decompression
Spine
Scoliosis
Ligaments
Proportional Hazards Models
Osteogenesis
Thorax
Multivariate Analysis
Demography
Wounds and Injuries

Keywords

  • Deformity
  • Scoliosis
  • Spinal cord injury

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Medicine(all)

Cite this

Incidence and the risk factors of spinal deformity in adult patient after spinal cord injury : a single center cohort study. / Yagi, Mitsuru; Hasegawa, Atsushi; Takemitsu, Masakazu; Yato, Yoshiyuki; Machida, Masafumi; Asazuma, Takashi.

In: European Spine Journal, Vol. 24, No. 1, 2014, p. 203-208.

Research output: Contribution to journalArticle

Yagi, Mitsuru ; Hasegawa, Atsushi ; Takemitsu, Masakazu ; Yato, Yoshiyuki ; Machida, Masafumi ; Asazuma, Takashi. / Incidence and the risk factors of spinal deformity in adult patient after spinal cord injury : a single center cohort study. In: European Spine Journal. 2014 ; Vol. 24, No. 1. pp. 203-208.
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abstract = "Study design: A retrospective consecutive case series of adult spinal cord injuries (SCIs) patients. Objective: To assess the incidence and risk factors of spinal deformity in a large sample of patients with SCIs. Summary of background data: Post-traumatic spinal deformities are well-recognized sequelae of SCIs. Despite the devastating complications for SCI patients with trunk imbalance, the incidence, clinical outcomes, and independent risk factors of scoliosis after SCI remain controversial. Materials and methods: We assessed 214 consecutive adult compressive SCI patients who were hospitalized in our hospital. We compared patients who developed spinal deformities with those who did not. Univariate and multivariate analyses to determine the independent risk factors were performed. Age, gender, etiology, ASIA grade (American Spinal Injury Association) surgery, and other demographic data were analyzed to determine the risk factors for developing a spinal deformity. Results: The average patient age was 58.3 years (20–86 years). The etiology was trauma (n = 158), ossification of ligament (n = 22), infectious (n = 17), and others. One hundred fifty-two patients had cervical spine involved, 62 had thoracic spine involved. 26 patients classified as ASIA A, 54 were ASIA B, 96 were ASIA C, and 42 were ASIA D 4. One hundred thirty-five patients had either decompression or decompression and fusion surgery. The incidence of spinal deformities was 21 {\%} (44/214). The mean Cobb angle was 28.9 degrees (13–38°). ASIA grade and surgery predicted the occurrence of spinal deformity in both the univariate model (ASIA grade, OR: 1.59 [95 {\%} CI: 1.04–2.44; P = 0.032]; Surgery, OR: 4.47 [95 {\%} CI: 1.89–10.06; P = 0.0007]) and the multivariate model (ASIA grade, OR: 1.63 [95 {\%} CI: 1.04–2.57; P = 0.033]; Surgery, OR: 4.59 [95 {\%} CI: 1.91–11.04; P = 0.0006]), whereas surgery was the most important risk factor in the Cox model (HR: 3.50 [95 {\%} CI: 1.56–7.88; P = 0.0025]). Conclusions: The SCI patients with high ASIA grades and those who had undergone surgery had a higher likelihood of developing a spinal deformity. Of these risk factors, surgery was the stronger risk factor.",
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N2 - Study design: A retrospective consecutive case series of adult spinal cord injuries (SCIs) patients. Objective: To assess the incidence and risk factors of spinal deformity in a large sample of patients with SCIs. Summary of background data: Post-traumatic spinal deformities are well-recognized sequelae of SCIs. Despite the devastating complications for SCI patients with trunk imbalance, the incidence, clinical outcomes, and independent risk factors of scoliosis after SCI remain controversial. Materials and methods: We assessed 214 consecutive adult compressive SCI patients who were hospitalized in our hospital. We compared patients who developed spinal deformities with those who did not. Univariate and multivariate analyses to determine the independent risk factors were performed. Age, gender, etiology, ASIA grade (American Spinal Injury Association) surgery, and other demographic data were analyzed to determine the risk factors for developing a spinal deformity. Results: The average patient age was 58.3 years (20–86 years). The etiology was trauma (n = 158), ossification of ligament (n = 22), infectious (n = 17), and others. One hundred fifty-two patients had cervical spine involved, 62 had thoracic spine involved. 26 patients classified as ASIA A, 54 were ASIA B, 96 were ASIA C, and 42 were ASIA D 4. One hundred thirty-five patients had either decompression or decompression and fusion surgery. The incidence of spinal deformities was 21 % (44/214). The mean Cobb angle was 28.9 degrees (13–38°). ASIA grade and surgery predicted the occurrence of spinal deformity in both the univariate model (ASIA grade, OR: 1.59 [95 % CI: 1.04–2.44; P = 0.032]; Surgery, OR: 4.47 [95 % CI: 1.89–10.06; P = 0.0007]) and the multivariate model (ASIA grade, OR: 1.63 [95 % CI: 1.04–2.57; P = 0.033]; Surgery, OR: 4.59 [95 % CI: 1.91–11.04; P = 0.0006]), whereas surgery was the most important risk factor in the Cox model (HR: 3.50 [95 % CI: 1.56–7.88; P = 0.0025]). Conclusions: The SCI patients with high ASIA grades and those who had undergone surgery had a higher likelihood of developing a spinal deformity. Of these risk factors, surgery was the stronger risk factor.

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KW - Deformity

KW - Scoliosis

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