Incidence of Antipsychotic-Associated Side Effects: Impact of Clinician Versus Patient Ratings and Change Versus Absolute Scores

Hiroyoshi Takeuchi, Gagan Fervaha, Gary Remington

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Objective This study aimed to compare (1) the detection rates of antipsychotic-associated side effects between clinician and patient ratings and (2) differences as a function of change and absolute score definitions. Methods: Data from phase 1 of the Clinical Antipsychotic Trials of Intervention Effectiveness (N = 1460) were analyzed. In this trial, 18 adverse events were systematically and concurrently assessed by clinicians and patients using a 4-point severity scale ranging from 0 (absent) to 3 (severe). The incidence of antipsychotic-associated side effects was calculated according to 2 definitions: change score (ie, higher score on the scale versus baseline) and absolute score (a score of 2 or 3 on the scale). In addition, patient and clinician concurrent detection rates were examined. Results The differences in incidence of antipsychotic-associated side effects between clinician and patient ratings were as small as 5.7% across the 2 definitions. The incidence of all side effects across clinician and patient ratings was approximately 2 times higher when using the change versus absolute score definition. Among the side effects detected by patients, 11 side effects were identified more frequently by clinicians, with 14.3% to 30.2% differences when using the change versus absolute score definition. Conversely, there was no difference of 10% or greater in patient or clinician concurrent detection rate on any item when using the absolute versus change score definition. Conclusions: Our findings suggest that patient ratings are in line with clinician ratings and that the change score definition may be superior for the assessment of antipsychotic-associated side effects in clinical studies.

Original languageEnglish
Pages (from-to)593-596
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume36
Issue number6
DOIs
Publication statusPublished - 2016 Dec 1

Keywords

  • adverse events
  • antipsychotics
  • definition
  • rating
  • schizophrenia
  • side effects

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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