Incidence of cytomegalovirus reactivation in patients with inflammatory connective tissue diseases who are under immunosuppressive therapy

Takehiko Mori, Hideto Kameda, Hiroe Ogawa, Atsushi Iizuka, Naoya Sekiguchi, Hirofumi Takei, Hayato Nagasawa, Michihide Tokuhira, Toshio Tanaka, Yumiko Saito, Koichi Amano, Toru Abe, Tsutomu Takeuchi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective. To evaluate the incidence and effect of cytomegalovirus (CMV) reactivation in patients with inflammatory connective tissue diseases (CTD) undergoing immunosuppressive therapy. Methods. A total of 18 consecutive CMV seropositive patients undergoing immunosuppressive therapy for inflammatory CTD were enrolled. CMV reactivation was determined by detection of CMV-DNA in peripheral blood leukocytes (PBL) or plasma using quantitative real-time polymerase chain reaction. Results. CMV reactivation was detected in PBL in 7 of 17 evaluable patients (41%), and in plasma in 5 of 17 patients (29%). Patients with detectable CMV-DNA in plasma were exclusively positive for CMV-DNA in PBL. Conclusion. Patients with inflammatory CTD under immunosuppressive therapy are at high risk for CMV reactivation. The clinical significance of such an event and indications for antiviral therapy should be examined further.

Original languageEnglish
Pages (from-to)1349-1351
Number of pages3
JournalJournal of Rheumatology
Volume31
Issue number7
Publication statusPublished - 2004 Jul 1

Keywords

  • Cytomegalovirus
  • Inflammatory connective tissue disease
  • Reactivation

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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    Mori, T., Kameda, H., Ogawa, H., Iizuka, A., Sekiguchi, N., Takei, H., Nagasawa, H., Tokuhira, M., Tanaka, T., Saito, Y., Amano, K., Abe, T., & Takeuchi, T. (2004). Incidence of cytomegalovirus reactivation in patients with inflammatory connective tissue diseases who are under immunosuppressive therapy. Journal of Rheumatology, 31(7), 1349-1351.