Incidence of headache after COVID-19 vaccination in patients with history of headache: A cross-sectional study

Koji Sekiguchi; Narumi Watanabe; Naoki Miyazaki; Kei Ishizuchi; Chisato Iba; Yu Tagashira; Shunsuke Uno; Mamoru Shibata; Naoki Hasegawa; Ryo Takemura; Jin Nakahara; Tsubasa Takizawa

doi:10.1177/03331024211038654

Incidence of headache after COVID-19 vaccination in patients with history of headache: A cross-sectional study

Koji Sekiguchi, Narumi Watanabe, Naoki Miyazaki, Kei Ishizuchi, Chisato Iba, Yu Tagashira, Shunsuke Uno, Mamoru Shibata, Naoki Hasegawa, Ryo Takemura, Jin Nakahara, Tsubasa Takizawa

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Background: Headache is an adverse event of coronavirus 2019 (COVID-19) vaccination. Whether patients with history of headache suffer more from vaccination-induced headaches is unknown. We aimed to uncover if headache patients develop more headaches after COVID-19 mRNA vaccination than healthy controls. Methods: We performed a questionnaire survey for nursing staff in our hospital from April to May 2021. Based on baseline characteristics, we divided the participants into migraine, non-migrainous headache, and healthy control, and examined the occurrence and features of headache after COVID-19 vaccinations. Results: We included 171 participants (15.2% migraine and 24.6% non-migrainous headache). Headache incidence after vaccinations was significantly higher in the migraine (69.2%) and non-migrainous headache (71.4%) groups than in the healthy control (37.9%) group. The incidence of headaches was significantly higher after the second dose compared to the first (45.6% vs. 20.5%). Conclusion: Migraineurs and non-migrainous headache participants developed more headaches compared to the healthy controls after COVID-19 vaccination.

Original language	English
Pages (from-to)	266-272
Number of pages	7
Journal	Cephalalgia
Volume	42
Issue number	3
DOIs	https://doi.org/10.1177/03331024211038654
Publication status	Published - 2022 Mar

Keywords

COVID-19
migraine
vaccination

ASJC Scopus subject areas

Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/03331024211038654

Cite this

@article{9739243d432640b7a318d8a5ffb7446c,

title = "Incidence of headache after COVID-19 vaccination in patients with history of headache: A cross-sectional study",

abstract = "Background: Headache is an adverse event of coronavirus 2019 (COVID-19) vaccination. Whether patients with history of headache suffer more from vaccination-induced headaches is unknown. We aimed to uncover if headache patients develop more headaches after COVID-19 mRNA vaccination than healthy controls. Methods: We performed a questionnaire survey for nursing staff in our hospital from April to May 2021. Based on baseline characteristics, we divided the participants into migraine, non-migrainous headache, and healthy control, and examined the occurrence and features of headache after COVID-19 vaccinations. Results: We included 171 participants (15.2% migraine and 24.6% non-migrainous headache). Headache incidence after vaccinations was significantly higher in the migraine (69.2%) and non-migrainous headache (71.4%) groups than in the healthy control (37.9%) group. The incidence of headaches was significantly higher after the second dose compared to the first (45.6% vs. 20.5%). Conclusion: Migraineurs and non-migrainous headache participants developed more headaches compared to the healthy controls after COVID-19 vaccination.",

keywords = "COVID-19, migraine, vaccination",

author = "Koji Sekiguchi and Narumi Watanabe and Naoki Miyazaki and Kei Ishizuchi and Chisato Iba and Yu Tagashira and Shunsuke Uno and Mamoru Shibata and Naoki Hasegawa and Ryo Takemura and Jin Nakahara and Tsubasa Takizawa",

note = "Funding Information: We would like to thank the nursing staff of Keio University Hospital who participated in this study. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The publication of this article was supported by JSPS KAKENHI (grant number 19K16989 to TT). Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The publication of this article was supported by JSPS KAKENHI (grant number 19K16989 to TT). Publisher Copyright: {\textcopyright} International Headache Society 2021.",

year = "2022",

month = mar,

doi = "10.1177/03331024211038654",

language = "English",

volume = "42",

pages = "266--272",

journal = "Cephalalgia",

issn = "0333-1024",

publisher = "SAGE Publications Ltd",

number = "3",

}

TY - JOUR

T1 - Incidence of headache after COVID-19 vaccination in patients with history of headache

T2 - A cross-sectional study

AU - Sekiguchi, Koji

AU - Watanabe, Narumi

AU - Miyazaki, Naoki

AU - Ishizuchi, Kei

AU - Iba, Chisato

AU - Tagashira, Yu

AU - Uno, Shunsuke

AU - Shibata, Mamoru

AU - Hasegawa, Naoki

AU - Takemura, Ryo

AU - Nakahara, Jin

AU - Takizawa, Tsubasa

N1 - Funding Information: We would like to thank the nursing staff of Keio University Hospital who participated in this study. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The publication of this article was supported by JSPS KAKENHI (grant number 19K16989 to TT). Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The publication of this article was supported by JSPS KAKENHI (grant number 19K16989 to TT). Publisher Copyright: © International Headache Society 2021.

PY - 2022/3

Y1 - 2022/3

N2 - Background: Headache is an adverse event of coronavirus 2019 (COVID-19) vaccination. Whether patients with history of headache suffer more from vaccination-induced headaches is unknown. We aimed to uncover if headache patients develop more headaches after COVID-19 mRNA vaccination than healthy controls. Methods: We performed a questionnaire survey for nursing staff in our hospital from April to May 2021. Based on baseline characteristics, we divided the participants into migraine, non-migrainous headache, and healthy control, and examined the occurrence and features of headache after COVID-19 vaccinations. Results: We included 171 participants (15.2% migraine and 24.6% non-migrainous headache). Headache incidence after vaccinations was significantly higher in the migraine (69.2%) and non-migrainous headache (71.4%) groups than in the healthy control (37.9%) group. The incidence of headaches was significantly higher after the second dose compared to the first (45.6% vs. 20.5%). Conclusion: Migraineurs and non-migrainous headache participants developed more headaches compared to the healthy controls after COVID-19 vaccination.

AB - Background: Headache is an adverse event of coronavirus 2019 (COVID-19) vaccination. Whether patients with history of headache suffer more from vaccination-induced headaches is unknown. We aimed to uncover if headache patients develop more headaches after COVID-19 mRNA vaccination than healthy controls. Methods: We performed a questionnaire survey for nursing staff in our hospital from April to May 2021. Based on baseline characteristics, we divided the participants into migraine, non-migrainous headache, and healthy control, and examined the occurrence and features of headache after COVID-19 vaccinations. Results: We included 171 participants (15.2% migraine and 24.6% non-migrainous headache). Headache incidence after vaccinations was significantly higher in the migraine (69.2%) and non-migrainous headache (71.4%) groups than in the healthy control (37.9%) group. The incidence of headaches was significantly higher after the second dose compared to the first (45.6% vs. 20.5%). Conclusion: Migraineurs and non-migrainous headache participants developed more headaches compared to the healthy controls after COVID-19 vaccination.

KW - COVID-19

KW - migraine

KW - vaccination

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SN - 0333-1024

VL - 42

SP - 266

EP - 272

JO - Cephalalgia

JF - Cephalalgia

IS - 3

ER -

Incidence of headache after COVID-19 vaccination in patients with history of headache: A cross-sectional study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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