Incidence of headache after COVID-19 vaccination in patients with history of headache: A cross-sectional study

Koji Sekiguchi, Narumi Watanabe, Naoki Miyazaki, Kei Ishizuchi, Chisato Iba, Yu Tagashira, Shunsuke Uno, Mamoru Shibata, Naoki Hasegawa, Ryo Takemura, Jin Nakahara, Tsubasa Takizawa

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Headache is an adverse event of coronavirus 2019 (COVID-19) vaccination. Whether patients with history of headache suffer more from vaccination-induced headaches is unknown. We aimed to uncover if headache patients develop more headaches after COVID-19 mRNA vaccination than healthy controls. Methods: We performed a questionnaire survey for nursing staff in our hospital from April to May 2021. Based on baseline characteristics, we divided the participants into migraine, non-migrainous headache, and healthy control, and examined the occurrence and features of headache after COVID-19 vaccinations. Results: We included 171 participants (15.2% migraine and 24.6% non-migrainous headache). Headache incidence after vaccinations was significantly higher in the migraine (69.2%) and non-migrainous headache (71.4%) groups than in the healthy control (37.9%) group. The incidence of headaches was significantly higher after the second dose compared to the first (45.6% vs. 20.5%). Conclusion: Migraineurs and non-migrainous headache participants developed more headaches compared to the healthy controls after COVID-19 vaccination.

Original languageEnglish
JournalCephalalgia
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • COVID-19
  • migraine
  • vaccination

ASJC Scopus subject areas

  • Clinical Neurology

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