Incomplete Androgen Insensitivity Associated with a Thermolabile Androgen Receptor

Tomonobu Hasegawa, Yukihiro Hasegawa, Taiji Aso, Shinobu Koto, Yutaka Tsuchiya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

One infant and a cousin with incomplete androgen insensitivity syndrome were reported. The familial pedigree showed that the disorder was inherited in three generations in X-linked recessive fashion. An androgen binding study of cultured genital skin fibroblast from patients showed normal maximum binding capacity and a normal apparent dissociation constant. Heat stability assay showed binding decreased to less than 30% at 41 °C compared with the amount at 30°C, indicating that the androgen receptor was thermolabile.

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalEndocrine Journal
Volume41
Issue number1
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Androgen-Insensitivity Syndrome
Androgen Receptors
Pedigree
Androgens
Fibroblasts
Hot Temperature
Skin

Keywords

  • Incomplete androgen insensitivity syndrome
  • Thermolabile androgen receptor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Incomplete Androgen Insensitivity Associated with a Thermolabile Androgen Receptor. / Hasegawa, Tomonobu; Hasegawa, Yukihiro; Aso, Taiji; Koto, Shinobu; Tsuchiya, Yutaka.

In: Endocrine Journal, Vol. 41, No. 1, 1994, p. 31-35.

Research output: Contribution to journalArticle

Hasegawa, Tomonobu ; Hasegawa, Yukihiro ; Aso, Taiji ; Koto, Shinobu ; Tsuchiya, Yutaka. / Incomplete Androgen Insensitivity Associated with a Thermolabile Androgen Receptor. In: Endocrine Journal. 1994 ; Vol. 41, No. 1. pp. 31-35.
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