Increase in corneal epithelial cell size with extended wear soft contact lenses depends on continuous wearing time

Kazuo Tsubota, Seiichiro Hata, Ikuko Toda, Yukiko Yagi, Miki Sakata, Jun Shimazaki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aim - Although 1 week of continuous wearing time (CWT) is recommended for extended wear soft contact lenses (EWSCL), there have been few studies concerning the appropriateness of this or other CWTs. The current study was undertaken to examine the effect of various CWTs on the cornea by observing the corneal epithelium. Methods - Specular microscopy was used to evaluate corneal epithelial changes induced by EWSCL in 19 myopic patients (24.0 (SD 6.7) years), divided into four groups: CWT of 0, 1, 3, and 6 days. Results - The initial mean cell area was 628.2 (13.4) μm2. After 6 months this was 629.3 (28.6) for daily wear (ns), and 660.0 (40.9) μm2, 727.7 (49.6) μm2 (p < 0.01), and 815.5 (67.2) μm2 (p < 0.01) for CWT of 1, 3, and 6 days respectively (p < 0.01). Conclusion - These findings indicate that the corneal epithelium changes proportionally with the CWT; the shorter the CWT, the better the epithelial morphology. This suggests that the CWT for EWSCL be minimised, so as to reduce the potential risk of contact lens related problems.

Original languageEnglish
Pages (from-to)144-147
Number of pages4
JournalBritish Journal of Ophthalmology
Volume80
Issue number2
Publication statusPublished - 1996 Feb

Fingerprint

Extended-Wear Contact Lenses
Hydrophilic Contact Lens
Cell Size
Epithelial Cells
Corneal Epithelium
Contact Lenses
Cornea
Microscopy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Increase in corneal epithelial cell size with extended wear soft contact lenses depends on continuous wearing time. / Tsubota, Kazuo; Hata, Seiichiro; Toda, Ikuko; Yagi, Yukiko; Sakata, Miki; Shimazaki, Jun.

In: British Journal of Ophthalmology, Vol. 80, No. 2, 02.1996, p. 144-147.

Research output: Contribution to journalArticle

Tsubota, Kazuo ; Hata, Seiichiro ; Toda, Ikuko ; Yagi, Yukiko ; Sakata, Miki ; Shimazaki, Jun. / Increase in corneal epithelial cell size with extended wear soft contact lenses depends on continuous wearing time. In: British Journal of Ophthalmology. 1996 ; Vol. 80, No. 2. pp. 144-147.
@article{0c2680725971411cbe18cd3180a7865b,
title = "Increase in corneal epithelial cell size with extended wear soft contact lenses depends on continuous wearing time",
abstract = "Aim - Although 1 week of continuous wearing time (CWT) is recommended for extended wear soft contact lenses (EWSCL), there have been few studies concerning the appropriateness of this or other CWTs. The current study was undertaken to examine the effect of various CWTs on the cornea by observing the corneal epithelium. Methods - Specular microscopy was used to evaluate corneal epithelial changes induced by EWSCL in 19 myopic patients (24.0 (SD 6.7) years), divided into four groups: CWT of 0, 1, 3, and 6 days. Results - The initial mean cell area was 628.2 (13.4) μm2. After 6 months this was 629.3 (28.6) for daily wear (ns), and 660.0 (40.9) μm2, 727.7 (49.6) μm2 (p < 0.01), and 815.5 (67.2) μm2 (p < 0.01) for CWT of 1, 3, and 6 days respectively (p < 0.01). Conclusion - These findings indicate that the corneal epithelium changes proportionally with the CWT; the shorter the CWT, the better the epithelial morphology. This suggests that the CWT for EWSCL be minimised, so as to reduce the potential risk of contact lens related problems.",
author = "Kazuo Tsubota and Seiichiro Hata and Ikuko Toda and Yukiko Yagi and Miki Sakata and Jun Shimazaki",
year = "1996",
month = "2",
language = "English",
volume = "80",
pages = "144--147",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - Increase in corneal epithelial cell size with extended wear soft contact lenses depends on continuous wearing time

AU - Tsubota, Kazuo

AU - Hata, Seiichiro

AU - Toda, Ikuko

AU - Yagi, Yukiko

AU - Sakata, Miki

AU - Shimazaki, Jun

PY - 1996/2

Y1 - 1996/2

N2 - Aim - Although 1 week of continuous wearing time (CWT) is recommended for extended wear soft contact lenses (EWSCL), there have been few studies concerning the appropriateness of this or other CWTs. The current study was undertaken to examine the effect of various CWTs on the cornea by observing the corneal epithelium. Methods - Specular microscopy was used to evaluate corneal epithelial changes induced by EWSCL in 19 myopic patients (24.0 (SD 6.7) years), divided into four groups: CWT of 0, 1, 3, and 6 days. Results - The initial mean cell area was 628.2 (13.4) μm2. After 6 months this was 629.3 (28.6) for daily wear (ns), and 660.0 (40.9) μm2, 727.7 (49.6) μm2 (p < 0.01), and 815.5 (67.2) μm2 (p < 0.01) for CWT of 1, 3, and 6 days respectively (p < 0.01). Conclusion - These findings indicate that the corneal epithelium changes proportionally with the CWT; the shorter the CWT, the better the epithelial morphology. This suggests that the CWT for EWSCL be minimised, so as to reduce the potential risk of contact lens related problems.

AB - Aim - Although 1 week of continuous wearing time (CWT) is recommended for extended wear soft contact lenses (EWSCL), there have been few studies concerning the appropriateness of this or other CWTs. The current study was undertaken to examine the effect of various CWTs on the cornea by observing the corneal epithelium. Methods - Specular microscopy was used to evaluate corneal epithelial changes induced by EWSCL in 19 myopic patients (24.0 (SD 6.7) years), divided into four groups: CWT of 0, 1, 3, and 6 days. Results - The initial mean cell area was 628.2 (13.4) μm2. After 6 months this was 629.3 (28.6) for daily wear (ns), and 660.0 (40.9) μm2, 727.7 (49.6) μm2 (p < 0.01), and 815.5 (67.2) μm2 (p < 0.01) for CWT of 1, 3, and 6 days respectively (p < 0.01). Conclusion - These findings indicate that the corneal epithelium changes proportionally with the CWT; the shorter the CWT, the better the epithelial morphology. This suggests that the CWT for EWSCL be minimised, so as to reduce the potential risk of contact lens related problems.

UR - http://www.scopus.com/inward/record.url?scp=0030028915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030028915&partnerID=8YFLogxK

M3 - Article

C2 - 8814745

AN - SCOPUS:0030028915

VL - 80

SP - 144

EP - 147

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 2

ER -