Increase in soluble CD138 in bronchoalveolar lavage fluid of multicentric Castleman's disease

Masaru Hasegawa, Tomoko Betsuyaku, Nobuya Yoshida, Yasuyuki Nasuhara, Ichiro Kinoshita, Satoshi Ohta, Tomoo Itoh, Pyong Woo Park, Masaharu Nishimura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Multicentric Castleman's disease (MCD) is a rare and often incurable lymphoproliferative disorder. It is typically a systemic illness, but occasionally manifests primarily as a pulmonary parenchymal disease with massive infiltration of CD138 (syndecan-1)-positive plasma cells. This is the first report to demonstrate a marked elevation of soluble CD138, despite the absence of plasma cells, in BAL fluid in an MCD patient with pulmonary involvement. This finding suggests that the quantitative measurement of soluble CD138 in BAL fluid may reflect plasma cell infiltration and disease activity in the lungs of patients with MCD.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalRespirology
Volume12
Issue number1
DOIs
Publication statusPublished - 2007 Jan

Keywords

  • BAL
  • IL-6
  • Multicentric Castleman's disease
  • Syndecan

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Increase in soluble CD138 in bronchoalveolar lavage fluid of multicentric Castleman's disease'. Together they form a unique fingerprint.

  • Cite this

    Hasegawa, M., Betsuyaku, T., Yoshida, N., Nasuhara, Y., Kinoshita, I., Ohta, S., Itoh, T., Park, P. W., & Nishimura, M. (2007). Increase in soluble CD138 in bronchoalveolar lavage fluid of multicentric Castleman's disease. Respirology, 12(1), 140-143. https://doi.org/10.1111/j.1440-1843.2006.00967.x