Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease

Nobuyuki Kobayashi, Shunichiro Shinagawa, Hidehito Niimura, Hisashi Kida, Tomoyuki Nagata, Kenji Tagai, Kazuya Shimada, Naomi Oka, Ryo Shikimoto, Yoshihiro Noda, Shinichiro Nakajima, Masaru Mimura, Masahiro Shigeta, Kazuhiro Kondo

Research output: Contribution to journalArticle

Abstract

Early diagnosis of dementia including Alzheimer’s disease (AD) is an urgent medical and welfare issue. However, to date, no simple biometrics have been available. We reported that blood DNA methylation levels of the COASY gene, which encodes coenzyme A synthase, were increased in individuals with AD and amnestic mild cognitive impairment (aMCI). The present study sought to replicate these findings with larger numbers of samples. Another objective was to clarify whether COASY methylation is associated with neurodegeneration through a comparison of AD, AD with cardiovascular disease (CVD), and vascular dementia (VaD). We measured blood COASY methylation levels in normal controls (NCs) (n = 200), and individuals with aMCI (n = 22), AD (n = 151), and VaD (n = 21). Compared with NCs, they were significantly higher in individuals with aMCI and AD. Further, they were significantly higher in AD patients without cardiovascular diseases compared to AD patients with them. These findings suggest that COASY methylation levels may be related to neurodegeneration in AD.

Original languageEnglish
Article number12217
JournalScientific reports
Volume10
Issue number1
DOIs
Publication statusPublished - 2020 Dec 1

ASJC Scopus subject areas

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    Kobayashi, N., Shinagawa, S., Niimura, H., Kida, H., Nagata, T., Tagai, K., Shimada, K., Oka, N., Shikimoto, R., Noda, Y., Nakajima, S., Mimura, M., Shigeta, M., & Kondo, K. (2020). Increased blood COASY DNA methylation levels a potential biomarker for early pathology of Alzheimer’s disease. Scientific reports, 10(1), [12217]. https://doi.org/10.1038/s41598-020-69248-9