Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1

Wolfram Jochum, Jean Pierre David, Candace Elliott, Anton Wutz, Hanns Plenk, Koichi Matsuo, Erwin F. Wagner

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that transgenic mice overexpressing Fra-1 in various organs develop a progressive increase in bone mass leading to osteosclerosis of the entire skeleton, which is due to a cell-autonomous increase in the number of mature osteoblasts. Moreover, osteoblast differentiation, but not proliferation, was enhanced and osteoclastogenesis was also elevated in vitro. These data indicate that, unlike c-Fos, which causes osteosarcomas, Fra-1 specifically enhances bone formation, which may be exploited to stimulate bone formation in pathological conditions.

Original languageEnglish
Pages (from-to)980-984
Number of pages5
JournalNature medicine
Volume6
Issue number9
DOIs
Publication statusPublished - 2000 Sep 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Jochum, W., David, J. P., Elliott, C., Wutz, A., Plenk, H., Matsuo, K., & Wagner, E. F. (2000). Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nature medicine, 6(9), 980-984. https://doi.org/10.1038/79676