Increased C-reactive protein expression exacerbates left ventricular dysfunction and remodeling after myocardial infarction

Toshiyuki Takahashi, Toshihisa Anzai, Hidehiro Kaneko, Yoshinori Mano, Atsushi Anzai, Toshiyuki Nagai, Takashi Kohno, Yuichiro Maekawa, Tsutomu Yoshikawa, Keiichi Fukuda, Satoshi Ogawa

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We previously reported serum C-reactive protein (CRP) elevation after acute myocardial infarction (MI) to be associated with adverse outcomes including cardiac rupture, left ventricular (LV) remodeling, and cardiac death. Experimental studies have indicated that CRP per se has various biological actions including proinflammatory and proapoptotic effects, suggesting a pathogenic role of CRP in the post-MI remodeling process. We tested the hypothesis that increased CRP expression would exacerbate adverse LV remodeling after MI via deleterious effects of CRP. Transgenic mice with human CRP expression (CRP-Tg) and their transgene-negative littermates (control) underwent left coronary artery ligation. There was no apparent difference in phenotypic features between CRP-Tg and control mice before MI. Although mortality and infarct size were similar in the two groups, CRP-Tg mice showed more LV dilation and worse LV function with more prominent cardiomyocyte hypertrophy and fibrosis in the noninfarcted regions after MI than controls. Histological evaluation conducted 1 wk post-MI revealed a higher rate of apoptosis and more macrophage infiltration in the border zones of infarcted hearts from CRP-Tg mice in relation to increased monocyte chemotactic protein (MCP)-1 expression and matrix metalloproteinase (MMP)-9 activity. Increased CRP expression exacerbates LV dysfunction and promotes adverse LV remodeling after MI in mice. The deleterious effect of CRP on post-MI LV remodeling may be associated with increased apoptotic rates, macrophage infiltration, MCP-1 expression, and MMP-9 activity in the border zone.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume299
Issue number6
DOIs
Publication statusPublished - 2010 Dec

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Ventricular Remodeling
Left Ventricular Dysfunction
C-Reactive Protein
Myocardial Infarction
Chemokine CCL2
Matrix Metalloproteinase 9
Macrophages
Heart Rupture
Protein C
Transgenes
Left Ventricular Function
Cardiac Myocytes
Hypertrophy
Transgenic Mice
Ligation
Blood Proteins
Dilatation
Coronary Vessels
Fibrosis

Keywords

  • Apoptosis
  • Macrophage

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Increased C-reactive protein expression exacerbates left ventricular dysfunction and remodeling after myocardial infarction. / Takahashi, Toshiyuki; Anzai, Toshihisa; Kaneko, Hidehiro; Mano, Yoshinori; Anzai, Atsushi; Nagai, Toshiyuki; Kohno, Takashi; Maekawa, Yuichiro; Yoshikawa, Tsutomu; Fukuda, Keiichi; Ogawa, Satoshi.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 299, No. 6, 12.2010.

Research output: Contribution to journalArticle

Takahashi, Toshiyuki ; Anzai, Toshihisa ; Kaneko, Hidehiro ; Mano, Yoshinori ; Anzai, Atsushi ; Nagai, Toshiyuki ; Kohno, Takashi ; Maekawa, Yuichiro ; Yoshikawa, Tsutomu ; Fukuda, Keiichi ; Ogawa, Satoshi. / Increased C-reactive protein expression exacerbates left ventricular dysfunction and remodeling after myocardial infarction. In: American Journal of Physiology - Heart and Circulatory Physiology. 2010 ; Vol. 299, No. 6.
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