Increased epicardial fat volume quantified by 64-multidetector computed tomography is associated with coronary atherosclerosis and totally occlusive lesions

Koji Ueno, Toshihisa Anzai, Masahiro Jinzaki, Minoru Yamada, Yusuke Jo, Yuichiro Maekawa, Akio Kawamura, Tsutomu Yoshikawa, Yutaka Tanami, Kozo Sato, Sachio Kuribayashi, Satoshi Ogawa

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Background: The relationship between the epicardial fat volume measured by 64-slice multidetector computed tomography (MDCT) and the extension and severity of coronary atherosclerosis was investigated. Methods and Results: Both MDCT and conventional coronary angiography (CAG) were performed in 71 consecutive patients who presented with effort angina. The volume of epicardial adipose tissue (EAT) was measured by MDCT. The severity of coronary atherosclerosis was assessed by evaluating the extension of coronary plaques in 790 segments using MDCT data, and the percentage diameter stenosis in 995 segments using CAG data. The estimated volume of EAT indexed by body surface area was defined as VEAT. Increased VEAT was associated with advanced age, male sex, degree of metabolic alterations, a history of acute coronary syndrome (ACS) and the presence of total occlusions, and showed positive correlation with the stenosis score (r=0.28, P=0.02) and the atheromatosis score (r=0.67, P<0.0001) of the coronary arteries. Multiple logistic regression analysis revealed an increased VEAT (≥50 cm3/m2) to be the strongest independent determinant of the presence of total occlusions (odds ratio 4.64, P=0.02). Conclusions: VEAT correlates with the degree of metabolic alterations and coronary atheromatosis. Excessive accumulation of EAT might contribute to the development of ACS and coronary total occlusions.

Original languageEnglish
Pages (from-to)1927-1933
Number of pages7
JournalCirculation Journal
Volume73
Issue number10
DOIs
Publication statusPublished - 2009 Oct

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Multidetector Computed Tomography
Coronary Artery Disease
Fats
Adipose Tissue
Acute Coronary Syndrome
Coronary Angiography
Pathologic Constriction
Coronary Occlusion
Body Surface Area
Coronary Vessels
Logistic Models
Odds Ratio
Regression Analysis

Keywords

  • Acute coronary syndrome
  • Atherosclerosis
  • Computed tomography
  • Coronary artery diseases
  • Occlusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Increased epicardial fat volume quantified by 64-multidetector computed tomography is associated with coronary atherosclerosis and totally occlusive lesions. / Ueno, Koji; Anzai, Toshihisa; Jinzaki, Masahiro; Yamada, Minoru; Jo, Yusuke; Maekawa, Yuichiro; Kawamura, Akio; Yoshikawa, Tsutomu; Tanami, Yutaka; Sato, Kozo; Kuribayashi, Sachio; Ogawa, Satoshi.

In: Circulation Journal, Vol. 73, No. 10, 10.2009, p. 1927-1933.

Research output: Contribution to journalArticle

Ueno, K, Anzai, T, Jinzaki, M, Yamada, M, Jo, Y, Maekawa, Y, Kawamura, A, Yoshikawa, T, Tanami, Y, Sato, K, Kuribayashi, S & Ogawa, S 2009, 'Increased epicardial fat volume quantified by 64-multidetector computed tomography is associated with coronary atherosclerosis and totally occlusive lesions', Circulation Journal, vol. 73, no. 10, pp. 1927-1933. https://doi.org/10.1253/circj.CJ-09-0266
Ueno, Koji ; Anzai, Toshihisa ; Jinzaki, Masahiro ; Yamada, Minoru ; Jo, Yusuke ; Maekawa, Yuichiro ; Kawamura, Akio ; Yoshikawa, Tsutomu ; Tanami, Yutaka ; Sato, Kozo ; Kuribayashi, Sachio ; Ogawa, Satoshi. / Increased epicardial fat volume quantified by 64-multidetector computed tomography is associated with coronary atherosclerosis and totally occlusive lesions. In: Circulation Journal. 2009 ; Vol. 73, No. 10. pp. 1927-1933.
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AU - Jo, Yusuke

AU - Maekawa, Yuichiro

AU - Kawamura, Akio

AU - Yoshikawa, Tsutomu

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AB - Background: The relationship between the epicardial fat volume measured by 64-slice multidetector computed tomography (MDCT) and the extension and severity of coronary atherosclerosis was investigated. Methods and Results: Both MDCT and conventional coronary angiography (CAG) were performed in 71 consecutive patients who presented with effort angina. The volume of epicardial adipose tissue (EAT) was measured by MDCT. The severity of coronary atherosclerosis was assessed by evaluating the extension of coronary plaques in 790 segments using MDCT data, and the percentage diameter stenosis in 995 segments using CAG data. The estimated volume of EAT indexed by body surface area was defined as VEAT. Increased VEAT was associated with advanced age, male sex, degree of metabolic alterations, a history of acute coronary syndrome (ACS) and the presence of total occlusions, and showed positive correlation with the stenosis score (r=0.28, P=0.02) and the atheromatosis score (r=0.67, P<0.0001) of the coronary arteries. Multiple logistic regression analysis revealed an increased VEAT (≥50 cm3/m2) to be the strongest independent determinant of the presence of total occlusions (odds ratio 4.64, P=0.02). Conclusions: VEAT correlates with the degree of metabolic alterations and coronary atheromatosis. Excessive accumulation of EAT might contribute to the development of ACS and coronary total occlusions.

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