Increased expression of type VI collagen genes in drug-induced gingival enlargement

Hideo Shikata; Nobuo Utsumi; Takahiro Shimojima; Yoshio Oda; Yasunori Okada

doi:10.1016/0014-5793(93)81681-O

Increased expression of type VI collagen genes in drug-induced gingival enlargement

Hideo Shikata, Nobuo Utsumi, Takahiro Shimojima, Yoshio Oda, Yasunori Okada

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Fibrotic gingival enlargements induced by phenytoin or nifedipine were examined with special reference to type VI collagen expression. Immuno-localization studies showed abnormal accumulation of type VI collagen around the collagen fiber bundles in the fibrotic gingival enlargements. Examination of total RNA extracted from fibroblasts and tissues of enlarged gingivae demonstrated increased type VI collagen steady-state mRNA levels. These results suggest that excessive deposition of type VI collagen in drug-induced gingival enlargement is attributed to increased expression of the collagen genes.

Original language	English
Pages (from-to)	65-68
Number of pages	4
Journal	FEBS Letters
Volume	334
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(93)81681-O
Publication status	Published - 1993 Nov 8
Externally published	Yes

Keywords

Gene expression
Gingival overgrowth
Type VI collagen

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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title = "Increased expression of type VI collagen genes in drug-induced gingival enlargement",

abstract = "Fibrotic gingival enlargements induced by phenytoin or nifedipine were examined with special reference to type VI collagen expression. Immuno-localization studies showed abnormal accumulation of type VI collagen around the collagen fiber bundles in the fibrotic gingival enlargements. Examination of total RNA extracted from fibroblasts and tissues of enlarged gingivae demonstrated increased type VI collagen steady-state mRNA levels. These results suggest that excessive deposition of type VI collagen in drug-induced gingival enlargement is attributed to increased expression of the collagen genes.",

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AU - Shikata, Hideo

AU - Utsumi, Nobuo

AU - Shimojima, Takahiro

AU - Oda, Yoshio

AU - Okada, Yasunori

PY - 1993/11/8

Y1 - 1993/11/8

N2 - Fibrotic gingival enlargements induced by phenytoin or nifedipine were examined with special reference to type VI collagen expression. Immuno-localization studies showed abnormal accumulation of type VI collagen around the collagen fiber bundles in the fibrotic gingival enlargements. Examination of total RNA extracted from fibroblasts and tissues of enlarged gingivae demonstrated increased type VI collagen steady-state mRNA levels. These results suggest that excessive deposition of type VI collagen in drug-induced gingival enlargement is attributed to increased expression of the collagen genes.

AB - Fibrotic gingival enlargements induced by phenytoin or nifedipine were examined with special reference to type VI collagen expression. Immuno-localization studies showed abnormal accumulation of type VI collagen around the collagen fiber bundles in the fibrotic gingival enlargements. Examination of total RNA extracted from fibroblasts and tissues of enlarged gingivae demonstrated increased type VI collagen steady-state mRNA levels. These results suggest that excessive deposition of type VI collagen in drug-induced gingival enlargement is attributed to increased expression of the collagen genes.

KW - Gene expression

KW - Gingival overgrowth

KW - Type VI collagen

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Increased expression of type VI collagen genes in drug-induced gingival enlargement

Abstract

Keywords

ASJC Scopus subject areas

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