Increased expression of type VI collagen genes in drug-induced gingival enlargement

Hideo Shikata, Nobuo Utsumi, Takahiro Shimojima, Yoshio Oda, Yasunori Okada

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Fibrotic gingival enlargements induced by phenytoin or nifedipine were examined with special reference to type VI collagen expression. Immuno-localization studies showed abnormal accumulation of type VI collagen around the collagen fiber bundles in the fibrotic gingival enlargements. Examination of total RNA extracted from fibroblasts and tissues of enlarged gingivae demonstrated increased type VI collagen steady-state mRNA levels. These results suggest that excessive deposition of type VI collagen in drug-induced gingival enlargement is attributed to increased expression of the collagen genes.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalFEBS Letters
Volume334
Issue number1
DOIs
Publication statusPublished - 1993 Nov 8

Fingerprint

Collagen Type VI
Genes
Pharmaceutical Preparations
Collagen
Phenytoin
Gingiva
Fibroblasts
Nifedipine
RNA
Tissue
Gene Expression
Messenger RNA
Fibers

Keywords

  • Gene expression
  • Gingival overgrowth
  • Type VI collagen

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Increased expression of type VI collagen genes in drug-induced gingival enlargement. / Shikata, Hideo; Utsumi, Nobuo; Shimojima, Takahiro; Oda, Yoshio; Okada, Yasunori.

In: FEBS Letters, Vol. 334, No. 1, 08.11.1993, p. 65-68.

Research output: Contribution to journalArticle

Shikata, H, Utsumi, N, Shimojima, T, Oda, Y & Okada, Y 1993, 'Increased expression of type VI collagen genes in drug-induced gingival enlargement', FEBS Letters, vol. 334, no. 1, pp. 65-68. https://doi.org/10.1016/0014-5793(93)81681-O
Shikata, Hideo ; Utsumi, Nobuo ; Shimojima, Takahiro ; Oda, Yoshio ; Okada, Yasunori. / Increased expression of type VI collagen genes in drug-induced gingival enlargement. In: FEBS Letters. 1993 ; Vol. 334, No. 1. pp. 65-68.
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