Abstract
Gene expression of matrix metalloproteinase 3 (MMP-3=stromelysin) was examined in the skin fibroblasts obtained from patients with severe recessive dystrophic epidermolysis bullosa (RDEB). Steady-state mRNA level of MMP-3 was selectively increased in the unstimulated RDEB cells by a post-transcriptional mechanism. A parallel study on the susceptibility of type VII collagen to MMPs revealed that this type of collagen is degraded by MMP-3, but not by MMP-1(collagenase). These data suggest that MMP-3 may play an important role in the blister formation of the skin in RDEB patients by the degradation of anchoring fibrils consisting of type VII collagen.
| Original language | English |
|---|---|
| Pages (from-to) | 1003-1008 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 174 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1991 Jan 31 |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa. / Sawamura, Daisuke; Sugawara, Takamitsu; Hashimoto, Isao; Bruckner-Tuderman, Leena; Fujimoto, Daisaburo; Okada, Yasunori; Utsumi, Nobuo; Shikata, Hideo.
In: Biochemical and Biophysical Research Communications, Vol. 174, No. 2, 31.01.1991, p. 1003-1008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa
AU - Sawamura, Daisuke
AU - Sugawara, Takamitsu
AU - Hashimoto, Isao
AU - Bruckner-Tuderman, Leena
AU - Fujimoto, Daisaburo
AU - Okada, Yasunori
AU - Utsumi, Nobuo
AU - Shikata, Hideo
PY - 1991/1/31
Y1 - 1991/1/31
N2 - Gene expression of matrix metalloproteinase 3 (MMP-3=stromelysin) was examined in the skin fibroblasts obtained from patients with severe recessive dystrophic epidermolysis bullosa (RDEB). Steady-state mRNA level of MMP-3 was selectively increased in the unstimulated RDEB cells by a post-transcriptional mechanism. A parallel study on the susceptibility of type VII collagen to MMPs revealed that this type of collagen is degraded by MMP-3, but not by MMP-1(collagenase). These data suggest that MMP-3 may play an important role in the blister formation of the skin in RDEB patients by the degradation of anchoring fibrils consisting of type VII collagen.
AB - Gene expression of matrix metalloproteinase 3 (MMP-3=stromelysin) was examined in the skin fibroblasts obtained from patients with severe recessive dystrophic epidermolysis bullosa (RDEB). Steady-state mRNA level of MMP-3 was selectively increased in the unstimulated RDEB cells by a post-transcriptional mechanism. A parallel study on the susceptibility of type VII collagen to MMPs revealed that this type of collagen is degraded by MMP-3, but not by MMP-1(collagenase). These data suggest that MMP-3 may play an important role in the blister formation of the skin in RDEB patients by the degradation of anchoring fibrils consisting of type VII collagen.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026013309&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(91)91518-H
DO - 10.1016/0006-291X(91)91518-H
M3 - Article
VL - 174
SP - 1003
EP - 1008
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -