Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa

Daisuke Sawamura, Takamitsu Sugawara, Isao Hashimoto, Leena Bruckner-Tuderman, Daisaburo Fujimoto, Yasunori Okada, Nobuo Utsumi, Hideo Shikata

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22 Citations (Scopus)

Abstract

Gene expression of matrix metalloproteinase 3 (MMP-3=stromelysin) was examined in the skin fibroblasts obtained from patients with severe recessive dystrophic epidermolysis bullosa (RDEB). Steady-state mRNA level of MMP-3 was selectively increased in the unstimulated RDEB cells by a post-transcriptional mechanism. A parallel study on the susceptibility of type VII collagen to MMPs revealed that this type of collagen is degraded by MMP-3, but not by MMP-1(collagenase). These data suggest that MMP-3 may play an important role in the blister formation of the skin in RDEB patients by the degradation of anchoring fibrils consisting of type VII collagen.

Original languageEnglish
Pages (from-to)1003-1008
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume174
Issue number2
DOIs
Publication statusPublished - 1991 Jan 31

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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