Increased intracellular Ca2+ is not coinherited with an inferred major gene locus for hypertension (ht) in the spontaneously hypertensive rat

Yoichi Ohno, Koichi Matsuo, Hiromichi Suzuki, Hisao Tanase, Toshiya Takano, Takao Saruta

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11 Citations (Scopus)


Hypertension is characterized by a complex mode of inheritance, consisting of the accumulation and interaction of major and minor genes. The existence of a single major gene locus (ht) has been demonstrated in the backcross analysis of spontaneously hypertensive rats (SHR) and normotensive Donryu rats. Intracellular Ca2+ concentration ([Ca2+](i)) determines the tonus of vascular smooth muscle. It has been hypothesized that abnormal Ca2+ transport is an inheritable trait with profound influence on the development of hypertension. Backcross analysis between SHR and Donryu rats was performed to demonstrate ht and to dissect polygenic hypertensive traits through ht and abnormal intracellular Ca2+ metabolism. Among the parental strains, systolic blood pressure and thrombin-stimulated [Ca2+](i) in platelets were significantly greater in SHR than in Donryu and F1 rats. The backcrossed rats were distributed into two clusters on a scattergram of blood pressure versus [Ca2+](i), demonstrating the existence of ht. The blood pressure level was correlated with thrombin-stimulated [Ca2+](i) in each cluster. Increased [Ca2+](i) in platelets was not coinherited with ht and was considered to be a minor inheritable hypertensive trait discriminated from ht. Therefore, [Ca2+](i) in platelets is an inadequate marker for searching ht.

Original languageEnglish
Pages (from-to)282-288
Number of pages7
JournalAmerican journal of hypertension
Issue number3
Publication statusPublished - 1997 Mar


  • Donryu rats
  • backcross analysis
  • calcium
  • genetics
  • intracellular Ca metabolism
  • platelet
  • polygene
  • spontaneously hypertensive rats

ASJC Scopus subject areas

  • Internal Medicine


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