Increased L1 retrotransposition in the neuronal genome in schizophrenia

Miki Bundo, Manabu Toyoshima, Yohei Okada, Wado Akamatsu, Junko Ueda, Taeko Nemoto-Miyauchi, Fumiko Sunaga, Michihiro Toritsuka, Daisuke Ikawa, Akiyoshi Kakita, Motoichiro Kato, Kiyoto Kasai, Toshifumi Kishimoto, Hiroyuki Nawa, Hideyuki Okano, Takeo Yoshikawa, Tadafumi Kato, Kazuya Iwamoto

Research output: Contribution to journalArticle

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Abstract

Recent studies indicate that long interspersed nuclear element-1 (L1) are mobilized in the genome of human neural progenitor cells and enhanced in Rett syndrome and ataxia telangiectasia. However, whether aberrant L1 retrotransposition occurs in mental disorders is unknown. Here, we report high L1 copy number in schizophrenia. Increased L1 was demonstrated in neurons from prefrontal cortex of patients and in induced pluripotent stem (iPS) cell-derived neurons containing 22q11 deletions. Whole-genome sequencing revealed brain-specific L1 insertion in patients localized preferentially to synapse- and schizophrenia-related genes. To study the mechanism of L1 transposition, we examined perinatal environmental risk factors for schizophrenia in animal models and observed an increased L1 copy number after immune activation by poly-I:C or epidermal growth factor. These findings suggest that hyperactive retrotransposition of L1 in neurons triggered by environmental and/or genetic risk factors may contribute to the susceptibility and pathophysiology of schizophrenia.

Original languageEnglish
Pages (from-to)306-313
Number of pages8
JournalNeuron
Volume81
Issue number2
DOIs
Publication statusPublished - 2014 Jan 22

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Schizophrenia
Genome
Neurons
Long Interspersed Nucleotide Elements
Rett Syndrome
Poly I-C
Induced Pluripotent Stem Cells
Ataxia Telangiectasia
Human Genome
Prefrontal Cortex
Epidermal Growth Factor
Mental Disorders
Synapses
Stem Cells
Animal Models
Brain
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bundo, M., Toyoshima, M., Okada, Y., Akamatsu, W., Ueda, J., Nemoto-Miyauchi, T., ... Iwamoto, K. (2014). Increased L1 retrotransposition in the neuronal genome in schizophrenia. Neuron, 81(2), 306-313. https://doi.org/10.1016/j.neuron.2013.10.053

Increased L1 retrotransposition in the neuronal genome in schizophrenia. / Bundo, Miki; Toyoshima, Manabu; Okada, Yohei; Akamatsu, Wado; Ueda, Junko; Nemoto-Miyauchi, Taeko; Sunaga, Fumiko; Toritsuka, Michihiro; Ikawa, Daisuke; Kakita, Akiyoshi; Kato, Motoichiro; Kasai, Kiyoto; Kishimoto, Toshifumi; Nawa, Hiroyuki; Okano, Hideyuki; Yoshikawa, Takeo; Kato, Tadafumi; Iwamoto, Kazuya.

In: Neuron, Vol. 81, No. 2, 22.01.2014, p. 306-313.

Research output: Contribution to journalArticle

Bundo, M, Toyoshima, M, Okada, Y, Akamatsu, W, Ueda, J, Nemoto-Miyauchi, T, Sunaga, F, Toritsuka, M, Ikawa, D, Kakita, A, Kato, M, Kasai, K, Kishimoto, T, Nawa, H, Okano, H, Yoshikawa, T, Kato, T & Iwamoto, K 2014, 'Increased L1 retrotransposition in the neuronal genome in schizophrenia', Neuron, vol. 81, no. 2, pp. 306-313. https://doi.org/10.1016/j.neuron.2013.10.053
Bundo M, Toyoshima M, Okada Y, Akamatsu W, Ueda J, Nemoto-Miyauchi T et al. Increased L1 retrotransposition in the neuronal genome in schizophrenia. Neuron. 2014 Jan 22;81(2):306-313. https://doi.org/10.1016/j.neuron.2013.10.053
Bundo, Miki ; Toyoshima, Manabu ; Okada, Yohei ; Akamatsu, Wado ; Ueda, Junko ; Nemoto-Miyauchi, Taeko ; Sunaga, Fumiko ; Toritsuka, Michihiro ; Ikawa, Daisuke ; Kakita, Akiyoshi ; Kato, Motoichiro ; Kasai, Kiyoto ; Kishimoto, Toshifumi ; Nawa, Hiroyuki ; Okano, Hideyuki ; Yoshikawa, Takeo ; Kato, Tadafumi ; Iwamoto, Kazuya. / Increased L1 retrotransposition in the neuronal genome in schizophrenia. In: Neuron. 2014 ; Vol. 81, No. 2. pp. 306-313.
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