Increased levels of Epstein-Barr virus DNA in lacrimal glands of Sjogren's syndrome patients

Kazuo Tsubota, H. Fujishima, I. Toda, S. Katagiri, Y. Kawashima, I. Saito

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Many Sjogren's syndrome patients complain primarily of dry eye. Epstein-Barr virus DNA has recently been found in the lacrimal glands of Sjogren's syndrome sufferers and normal individuals, and lacrimal glands are thought to be a target organ for latent Epstein-Barr virus infection. In this study, we performed lacrimal and salivary gland biopsies on 9 Sjogren's syndrome patients. Extracted Epstein-Barr virus DNA was assayed by polymerase chain reaction and compared to that of healthy individuals. An increased level of Epstein-Barr virus DNA was observed in all of the lacrimal glands and 8 of the 9 salivary glands from the Sjogren's syndrome patients. However, the amount of genome in the lacrimal gland was more than 10 times that in the salivary glands, not only in the Sjogren's syndrome patients but also in the controls. This may explain the pathogenesis of dry eye in patients with Sjogren's syndrome, and why the lacrimal gland tends to be so prominently affected. It may also suggest a therapeutic approach for this and possibly other types of dry eye.

Original languageEnglish
Pages (from-to)425-430
Number of pages6
JournalActa Ophthalmologica Scandinavica
Volume73
Issue number5
Publication statusPublished - 1995

Fingerprint

Lacrimal Apparatus
Sjogren's Syndrome
Human Herpesvirus 4
DNA
Salivary Glands
Epstein-Barr Virus Infections
Genome
Biopsy
Polymerase Chain Reaction

Keywords

  • Epstein-Barr virus DNA
  • Lacrimal gland
  • Polymerase chain reaction
  • Salivary gland
  • Sjogren's syndrome

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tsubota, K., Fujishima, H., Toda, I., Katagiri, S., Kawashima, Y., & Saito, I. (1995). Increased levels of Epstein-Barr virus DNA in lacrimal glands of Sjogren's syndrome patients. Acta Ophthalmologica Scandinavica, 73(5), 425-430.

Increased levels of Epstein-Barr virus DNA in lacrimal glands of Sjogren's syndrome patients. / Tsubota, Kazuo; Fujishima, H.; Toda, I.; Katagiri, S.; Kawashima, Y.; Saito, I.

In: Acta Ophthalmologica Scandinavica, Vol. 73, No. 5, 1995, p. 425-430.

Research output: Contribution to journalArticle

Tsubota, K, Fujishima, H, Toda, I, Katagiri, S, Kawashima, Y & Saito, I 1995, 'Increased levels of Epstein-Barr virus DNA in lacrimal glands of Sjogren's syndrome patients', Acta Ophthalmologica Scandinavica, vol. 73, no. 5, pp. 425-430.
Tsubota, Kazuo ; Fujishima, H. ; Toda, I. ; Katagiri, S. ; Kawashima, Y. ; Saito, I. / Increased levels of Epstein-Barr virus DNA in lacrimal glands of Sjogren's syndrome patients. In: Acta Ophthalmologica Scandinavica. 1995 ; Vol. 73, No. 5. pp. 425-430.
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