Increased levels of plasma ghrelin in peptic ulcer disease

Hidekazu Suzuki, Tatsuhiro Masaoka, Y. Nomoto, H. Hosoda, M. Mori, T. Nishizawa, Y. Minegishi, K. Kangawa, T. Hibi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Ghrelin is a novel appetite-promoting peptide secreted primarily from the A-like cells in the gastric fundic mucosa. As gastric inflammation caused by Helicobacter pylori infection extends, the number of ghrelin-producing A-like cells is diminished and gastric ghrelin content decreases significantly. We previously reported that plasma levels of ghrelin, which correlated well with the serum levels of pepsinogen (PG) I and PG I/II ratio, decreased as gastric mucosal atrophy increased in non-ulcerogenic conditions and that plasma ghrelin level increased in rats with cysteamine-induced duodenal ulcer. Aim: To investigate the plasma levels of ghrelin in patients with peptic ulcer disease. Patients and Methods: Two hundred and eighty-six patients with epigastric symptoms, who underwent upper gastrointestinal endoscopy, were enrolled. Blood samples were collected after a 12-h fast before endoscopy. Patients were divided into four groups, namely chronic gastritis with high PG (n = 197), chronic gastritis with low PG (n = 58), duodenal ulcer (n = 14) and gastric ulcer (n = 17) and plasma concentrations of total and active ghrelin as well as serum concentrations of PG I and PG II were measured by radioimmunoassay. Six patients with duodenal ulcer and seven with gastric ulcer were also examined after ulcer healing. Results: Plasma ghrelin levels were significantly higher in patients with duodenal ulcer or gastric ulcer than in those without ulcers. Elevated plasma total ghrelin levels did not significantly change after the healing of ulcers. Conclusions: Plasma ghrelin levels were significantly higher in patients with peptic ulcer than in those with gastritis without ulcer. This finding suggests a possible relationship between mucosal injury susceptibility and elevated fasting plasma ghrelin.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalAlimentary Pharmacology and Therapeutics
Volume24
Issue numberSUPPL.4
DOIs
Publication statusPublished - 2006 Dec

Fingerprint

Ghrelin
Peptic Ulcer
Pepsinogen A
Duodenal Ulcer
Ulcer
Gastritis
Stomach Ulcer
Pepsinogen C
Stomach
Cysteamine
Gastrointestinal Contents
Gastrointestinal Endoscopy
Helicobacter Infections
Appetite
Gastric Mucosa
Serum
Helicobacter pylori
Endoscopy
Atrophy
Radioimmunoassay

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Suzuki, H., Masaoka, T., Nomoto, Y., Hosoda, H., Mori, M., Nishizawa, T., ... Hibi, T. (2006). Increased levels of plasma ghrelin in peptic ulcer disease. Alimentary Pharmacology and Therapeutics, 24(SUPPL.4), 120-126. https://doi.org/10.1111/j.1365-2036.2006.00034.x

Increased levels of plasma ghrelin in peptic ulcer disease. / Suzuki, Hidekazu; Masaoka, Tatsuhiro; Nomoto, Y.; Hosoda, H.; Mori, M.; Nishizawa, T.; Minegishi, Y.; Kangawa, K.; Hibi, T.

In: Alimentary Pharmacology and Therapeutics, Vol. 24, No. SUPPL.4, 12.2006, p. 120-126.

Research output: Contribution to journalArticle

Suzuki, H, Masaoka, T, Nomoto, Y, Hosoda, H, Mori, M, Nishizawa, T, Minegishi, Y, Kangawa, K & Hibi, T 2006, 'Increased levels of plasma ghrelin in peptic ulcer disease', Alimentary Pharmacology and Therapeutics, vol. 24, no. SUPPL.4, pp. 120-126. https://doi.org/10.1111/j.1365-2036.2006.00034.x
Suzuki, Hidekazu ; Masaoka, Tatsuhiro ; Nomoto, Y. ; Hosoda, H. ; Mori, M. ; Nishizawa, T. ; Minegishi, Y. ; Kangawa, K. ; Hibi, T. / Increased levels of plasma ghrelin in peptic ulcer disease. In: Alimentary Pharmacology and Therapeutics. 2006 ; Vol. 24, No. SUPPL.4. pp. 120-126.
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AU - Masaoka, Tatsuhiro

AU - Nomoto, Y.

AU - Hosoda, H.

AU - Mori, M.

AU - Nishizawa, T.

AU - Minegishi, Y.

AU - Kangawa, K.

AU - Hibi, T.

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