Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients

Shinta Mizuno, Masatoshi Wakui, Yujiro Machida, Naoki Hosoe, Tadakazu Hisamatsu, Takashi Ishida, Kaori Kameyama, Makoto Naganuma, Takanori Kanai

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1 Citation (Scopus)

Abstract

Rationale: Mesenteric panniculitis (MP) is a rare disease with abdominal and systemic symptoms and is characterized by nonspecific inflammation, fat necrosis, and fibrosis in mesenteric fat. Active inflammatory responses may increase levels of prostaglandin E-major urinary metabolite (PGE-MUM), which was reported to reflect the disease activity of ulcerative colitis and chronic fibrosing interstitial pneumonia. We recently experienced a case with elevated PGE-MUM at the time of diagnosis of MP and we investigated the potential of PGE-MUM as a biomarker. Patient concern: In this report we described 2 active mesenteric panniculitis patients with high PGE-MUM levels. Diagnoses: Mesenteric panniculitis Interventions: Both MP patients were measured the levels of PGE-MUM. Outcomes: Both MP patients exhibited high levels of PGE-MUM before treatment. In one, the levels were sensitively correlated with clinical symptoms and serological markers on steroids. Lessons: The study observations suggest the potential of PGE-MUM to reflect the disease activity of MP. To verify its use, more findings based on clinical studies should be accumulated.

Original languageEnglish
Article numbere9237
JournalMedicine (United States)
Volume96
Issue number51
DOIs
Publication statusPublished - 2017 Dec 1

Keywords

  • biomarker
  • mesenteric panniculitis
  • prostaglandin E-major urinary metabolite

ASJC Scopus subject areas

  • Medicine(all)

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