Increased lymphocyte transport by lipid absorption in rat mesenteric lymphatics

S. Miura, E. Sekizuka, H. Nagata, C. Oshio, H. Minamitani, M. Suematsu, M. Suzuki, Y. Hamada, K. Kobayashi, H. Asakura, M. Tsuchiya

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The effect of olive oil administration on lymphocyte transport through mesenteric lymphatics was examined to see the possible involvement of nutritional absorption in lymphocyte traffic from the intestinal mucosa. After the olive oil administration to rats, remarkable increase in lymphocyte flux was observed within 2 h in lymph samples collected from rats with lymphatic fistula. The use of a high-speed microscopic video system made it possible to analyze accurately the lymphocyte transport in rapid movement that could not be detected by any of the ordinary video systems. The direct observation of mesenteric collecting lymphatics by this system showed an increment of lymphocyte transport from the intestinal mucosa lipid absorption in 2 h. The contraction frequency of intestinal collecting lymphatics was also enhanced by olive oil administration. The densitometric analysis on video image was applied to estimate the extent of lipid absorption. The combination of a high-speed video system and the densitometric analysis revealed that the increase in lymphocyte flux occurred before lipid absorption reached its maximum and also demonstrated that the lymphocyte transport returned to control levels under the maximal absorptive condition. The results suggest that the fat absorption could be an important factor influencing the lymphocyte transport in the lymphatic system of intestine.

Original languageEnglish
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume253
Issue number5
Publication statusPublished - 1987

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Lymphocytes
Lipids
Lymphatic System
Intestinal Mucosa
Lymph
Fistula
Intestines
Fats
Observation
Olive Oil

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Miura, S., Sekizuka, E., Nagata, H., Oshio, C., Minamitani, H., Suematsu, M., ... Tsuchiya, M. (1987). Increased lymphocyte transport by lipid absorption in rat mesenteric lymphatics. American Journal of Physiology - Gastrointestinal and Liver Physiology, 253(5).

Increased lymphocyte transport by lipid absorption in rat mesenteric lymphatics. / Miura, S.; Sekizuka, E.; Nagata, H.; Oshio, C.; Minamitani, H.; Suematsu, M.; Suzuki, M.; Hamada, Y.; Kobayashi, K.; Asakura, H.; Tsuchiya, M.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 253, No. 5, 1987.

Research output: Contribution to journalArticle

Miura, S, Sekizuka, E, Nagata, H, Oshio, C, Minamitani, H, Suematsu, M, Suzuki, M, Hamada, Y, Kobayashi, K, Asakura, H & Tsuchiya, M 1987, 'Increased lymphocyte transport by lipid absorption in rat mesenteric lymphatics', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 253, no. 5.
Miura, S. ; Sekizuka, E. ; Nagata, H. ; Oshio, C. ; Minamitani, H. ; Suematsu, M. ; Suzuki, M. ; Hamada, Y. ; Kobayashi, K. ; Asakura, H. ; Tsuchiya, M. / Increased lymphocyte transport by lipid absorption in rat mesenteric lymphatics. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 1987 ; Vol. 253, No. 5.
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AU - Suematsu, M.

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