Increased non-relapse mortality due to high-dose cytarabine plus CY/TBI in BMT/PBSCT for acute lymphoblastic leukaemia in adults

the Japan Society for Haematopoietic Cell Transplantation

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5 Citations (Scopus)

Abstract

The efficacy of high-dose cytarabine (HDCA) plus cyclophosphamide/total-body irradiation (CY/TBI) has been proved in cord blood transplantation (CBT) for acute lymphoblastic leukaemia (ALL), but not in bone marrow or peripheral blood stem cell transplantation (BMT/PBSCT). In this cohort study, we compared the prognosis of CY/TBI (N = 1244) and HDCA/CY/TBI (N = 316) regimens in BMT/PBSCT for ALL. The addition of HDCA decreased post-transplant relapse, while significantly increasing non-relapse mortality (risk ratio, 1·33), and overall survival was not improved. The positive effects of HDCA reported in CBT cannot be extrapolated to BMT/PBSCT, and HDCA may not be recommended in these procedures.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalBritish Journal of Haematology
Volume178
Issue number1
DOIs
Publication statusPublished - 2017 Jul

Keywords

  • BMT/PBSCT
  • acute lymphoblastic leukaemia
  • allogeneic transplantation
  • conditioning regimens
  • high-dose cytarabine

ASJC Scopus subject areas

  • Hematology

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