Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice

Hitoshi Kajigaya, Kenji Tanaka, Akiko Hayashi, Ayaka Suzuki, Tomoko Ishibashi, Kazuhiro Ikenaka, Hiroko Baba

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Sulfatide is a myelin glycolipid that functions in the formation of paranodal axoglial junctions in vivo and in the regulation of oligodendrocyte differentiation in vitro. Cerebroside sulfotransferase (CST) catalyzes the production of two sulfated glycolipids, sulfatide and proligodendroblast antigen, in oligodendrocyte lineage cells. Recent studies have demonstrated significant increases in oligodendrocytes from the myelination stage through adulthood in brain and spinal cord under CST-deficient conditions. However, whether these result from excess migration or in situ proliferation during development is undetermined. In the present study, CST-deficient optic nerves were used to examine migration and proliferation of oligodendrocyte precursor cells (OPCs) under sulfated glycolipid-deficient conditions. In adults, more NG2-positive OPCs and fully differentiated cells were observed. In developing optic nerves, the number of cells at the leading edge of migration was similar in CST-deficient and wild-type mice. However, BrdUD proliferating OPCs were more abundant in CST-deficient mice. These results suggest that sulfated glycolipids may be involved in proliferation of OPCs in vivo.

Original languageEnglish
Pages (from-to)415-424
Number of pages10
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume87
Issue number7
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

galactosylceramide sulfotransferase
knockout mice
cerebrosides
sulfotransferases
Oligodendroglia
nerves
Optic Nerve
optics
Knockout Mice
nerve tissue
glycolipids
mice
cells
Sulfoglycosphingolipids
myelin
spinal cord
antigens
leading edges
myelination
brain

Keywords

  • Cerebroside sulfotransferase
  • Myelination
  • Oligodendrocyte
  • Optic nerve
  • Sulfatide

ASJC Scopus subject areas

  • General

Cite this

Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice. / Kajigaya, Hitoshi; Tanaka, Kenji; Hayashi, Akiko; Suzuki, Ayaka; Ishibashi, Tomoko; Ikenaka, Kazuhiro; Baba, Hiroko.

In: Proceedings of the Japan Academy Series B: Physical and Biological Sciences, Vol. 87, No. 7, 2011, p. 415-424.

Research output: Contribution to journalArticle

Kajigaya, Hitoshi ; Tanaka, Kenji ; Hayashi, Akiko ; Suzuki, Ayaka ; Ishibashi, Tomoko ; Ikenaka, Kazuhiro ; Baba, Hiroko. / Increased numbers of oligodendrocyte lineage cells in the optic nerves of cerebroside sulfotransferase knockout mice. In: Proceedings of the Japan Academy Series B: Physical and Biological Sciences. 2011 ; Vol. 87, No. 7. pp. 415-424.
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