Increased oxidative stress and coenzyme Q10 deficiency in centenarians

Midori Nagase, Yorihiro Yamamoto, Nozomi Matsumoto, Yasumichi Arai, Nobuyoshi Hirose

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aging populations are expanding worldwide, and the increasing requirement for nursing care has become a serious problem. Furthermore, successful aging is one of the highest priorities for individuals and societies. Centenarians are an informative cohort to study and inflammation has been found to be a key factor in predicting cognition and physical capabilities. Inflammation scores have been determined based on the levels of cytokines and C reactive protein, however, serum antioxidants and lipid profiles have not been carefully examined. We found that the redox balance of coenzyme Q10 significantly shifted to the oxidized form and levels of strong antioxidants, such as ascorbic acid and unconjugated bilirubin, decreased significantly compared to 76 yearold controls, indicating an increased oxidative stress in centenarians. Levels of uric acid, an endogenous peroxynitrite scavenger, remained unchanged, suggesting that centenarians were experiencing moderate, chronic inflammatory conditions. Centenarians exhibited a hypocholesterolemic condition, while an increase in the ratio of free cholesterol to cholesterol esters sug gests some impairment of liver function. Serum free fatty acids and monoenoic acid composition, markers of tissue oxidative damage, were significantly decreased in centenarians, indicating an impairment in the tissue repair system. Despite an elevation of the coenzyme Q10 binding protein Psap, serum total coenzyme Q10 levels decreased in centenarians. This suggests a serious deficiency of coenzyme Q10 in tissues, since tissue levels of coenzyme Q10 significantly decrease with age. Therefore, coenzyme Q10 supple mentation could be beneficial for centenarians.

Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalJournal of Clinical Biochemistry and Nutrition
Volume63
Issue number2
DOIs
Publication statusPublished - 2018 Sep 1

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Keywords

  • Centenarians
  • Cholesterol metabolism
  • Coenzyme Q10
  • Free fatty acids and their composition
  • Prosaposin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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