Increased proportion of a CD38highIgD+ B cell subset in peripheral blood is associated with clinical and immunological features in patients with primary Sjögren's syndrome

Eriko Ishioka-Takei, Keiko Yoshimoto, Katsuya Suzuki, Ayumi Nishikawa, Hidekata Yasuoka, Kunihiro Yamaoka, Tsutomu Takeuchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We investigated the correlation between the increased proportion of peripheral B cell subsets and clinical and immunological features in primary Sjögren's syndrome (pSS). We found that the proportion of CD19+ B cells was significantly increased in pSS as compared with HC and was correlated with serum IgG levels. Moreover, in vitro IgG production by CD19+ B cells was significantly increased in pSS and was positively and significantly correlated with serum IgG levels. FACS analysis revealed that the proportions of peripherally CD38highIgD+ B cells and CD38highIgD- B cells were significantly increased in pSS. In addition, the proportion of CD38highIgD+ B cells positively correlated with ESSDAI scores and serum levels of IgG, anti-Ro/SSA and anti-La/SSB antibodies while that of CD38highIgD- B cells showed no correlation with these parameters. Our data suggest that increased proportion of CD38highIgD+ B cells in pSS is involved in IgG overproduction including autoantibodies, and correlates with disease progression.

Original languageEnglish
JournalClinical Immunology
DOIs
Publication statusAccepted/In press - 2017

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B-Lymphocyte Subsets
B-Lymphocytes
Immunoglobulin G
Serum
Autoantibodies
Disease Progression
Antibodies

Keywords

  • Autoantibodies
  • B cell
  • CD38
  • ESSDAI
  • IgD
  • IgG
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Increased proportion of a CD38highIgD+ B cell subset in peripheral blood is associated with clinical and immunological features in patients with primary Sjögren's syndrome. / Ishioka-Takei, Eriko; Yoshimoto, Keiko; Suzuki, Katsuya; Nishikawa, Ayumi; Yasuoka, Hidekata; Yamaoka, Kunihiro; Takeuchi, Tsutomu.

In: Clinical Immunology, 2017.

Research output: Contribution to journalArticle

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AU - Ishioka-Takei, Eriko

AU - Yoshimoto, Keiko

AU - Suzuki, Katsuya

AU - Nishikawa, Ayumi

AU - Yasuoka, Hidekata

AU - Yamaoka, Kunihiro

AU - Takeuchi, Tsutomu

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AB - We investigated the correlation between the increased proportion of peripheral B cell subsets and clinical and immunological features in primary Sjögren's syndrome (pSS). We found that the proportion of CD19+ B cells was significantly increased in pSS as compared with HC and was correlated with serum IgG levels. Moreover, in vitro IgG production by CD19+ B cells was significantly increased in pSS and was positively and significantly correlated with serum IgG levels. FACS analysis revealed that the proportions of peripherally CD38highIgD+ B cells and CD38highIgD- B cells were significantly increased in pSS. In addition, the proportion of CD38highIgD+ B cells positively correlated with ESSDAI scores and serum levels of IgG, anti-Ro/SSA and anti-La/SSB antibodies while that of CD38highIgD- B cells showed no correlation with these parameters. Our data suggest that increased proportion of CD38highIgD+ B cells in pSS is involved in IgG overproduction including autoantibodies, and correlates with disease progression.

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