Increased respiratory burst of leukocytes in inflammatory bowel diseases - The analysis of free radical generation by using chemiluminescence probe

M. Suematsu, M. Suzuki, T. Kitahora, S. Miura, K. Suzuki, T. Hibi, M. Watanabe, H. Nagata, H. Asakura, M. Tsuchiya

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Abstract

Respiratory burst of leukocytes was determined in Crohn's disease, intestinal Behcet's disease and ulcerative colitis by using chemiluminescence assay. Oxygen-derived free radicals of monocytes in Crohn's disease and those of polymorphonuclear leukocytes in intestinal Behcet's disease were significantly raised as compared with those of controls. In ulcerative colitis, respiratory burst activities of both polymorphonuclear leukocytes and monocytes were found to be highly associated with the disease activities. These results suggest that active oxygen species from leukocytes may participate in the formation of intestinal mucosal lesions in inflammatory bowel diseases via auto-oxidative process.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalJournal of Clinical and Laboratory Immunology
Volume24
Issue number3
Publication statusPublished - 1987 Dec 1

ASJC Scopus subject areas

  • Immunology

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    Suematsu, M., Suzuki, M., Kitahora, T., Miura, S., Suzuki, K., Hibi, T., Watanabe, M., Nagata, H., Asakura, H., & Tsuchiya, M. (1987). Increased respiratory burst of leukocytes in inflammatory bowel diseases - The analysis of free radical generation by using chemiluminescence probe. Journal of Clinical and Laboratory Immunology, 24(3), 125-128.