Increased risk of obesity resulting from the interaction between high energy intake and the Trp64Arg polymorphism of the β3-adrenergic receptor gene in healthy Japanese men

Koichi Miyaki, Shinya Sutani, Haruhito Kikuchi, Izumi Takei, Mitsuru Murata, Kiyoaki Watanabe, Kazuyuki Omae

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Few studies have investigated the interaction between the Trp64Arg polymorphism of the β3-adrenergic receptor gene (ADRB3) and environmental factors. This study aimed to investigate whether energy intake affects the relationship between this polymorphism and obesity. Methods: Healthy Japanese men (n=295; age 46.1±11.5 years (mean ±standard deviation); waist circumference 83.9±9.3 cm; body mass index (BMI) 23.3±3.3 kg/m2) recruited in a Japanese chemical industry firm were eligible for analysis. Daily energy intake, protein, fat, and carbohydrate (PFC) ratio and daily physical activity were assessed by self-reported questionnaires. Genotyping for the polymorphism was performed with written informed consent. Results: When the subjects were classified into two groups according to presence of the polymorphism, the groups were not significantly different in waist circumference or BMI. Quartile classification of energy intake, however, demonstrated a significantly larger ratio of obese subjects to non-obese subjects in the group with the polymorphism in the highest 4th quartile alone. Multiple logistic regression analysis also revealed that the presence of the polymorphism increased the risk of obesity significantly in the 4th quartile alone (adjusted odds ratio=3.37, 95% confidence interval=1.12-10.2). Conclusion: Presence of the polymorphism alone does not significantly increase the risk of obesity. However, high energy intake interacts with the polymorphism and leads to a significant increase in risk of obesity. The Trp64Arg polymorphism of ADRB3 warrants consideration, along with other polymorphisms involved in the development of obesity, for tailor-made prevention of obesity.

Original languageEnglish
Pages (from-to)203-210
Number of pages8
JournalJournal of Epidemiology
Volume15
Issue number6
DOIs
Publication statusPublished - 2005 Nov 7

Fingerprint

Energy Intake
Adrenergic Receptors
Obesity
Genes
Waist Circumference
Body Mass Index
Chemical Industry
Informed Consent
Logistic Models
Fats
Odds Ratio
Regression Analysis
Carbohydrates
Confidence Intervals
Exercise
Proteins

Keywords

  • Adrenergic
  • Beta-3
  • Energy intake
  • Obesity
  • Polymorphism
  • Questionnaires
  • Receptors
  • Single nucleotide

ASJC Scopus subject areas

  • Epidemiology

Cite this

Increased risk of obesity resulting from the interaction between high energy intake and the Trp64Arg polymorphism of the β3-adrenergic receptor gene in healthy Japanese men. / Miyaki, Koichi; Sutani, Shinya; Kikuchi, Haruhito; Takei, Izumi; Murata, Mitsuru; Watanabe, Kiyoaki; Omae, Kazuyuki.

In: Journal of Epidemiology, Vol. 15, No. 6, 07.11.2005, p. 203-210.

Research output: Contribution to journalArticle

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abstract = "Background: Few studies have investigated the interaction between the Trp64Arg polymorphism of the β3-adrenergic receptor gene (ADRB3) and environmental factors. This study aimed to investigate whether energy intake affects the relationship between this polymorphism and obesity. Methods: Healthy Japanese men (n=295; age 46.1±11.5 years (mean ±standard deviation); waist circumference 83.9±9.3 cm; body mass index (BMI) 23.3±3.3 kg/m2) recruited in a Japanese chemical industry firm were eligible for analysis. Daily energy intake, protein, fat, and carbohydrate (PFC) ratio and daily physical activity were assessed by self-reported questionnaires. Genotyping for the polymorphism was performed with written informed consent. Results: When the subjects were classified into two groups according to presence of the polymorphism, the groups were not significantly different in waist circumference or BMI. Quartile classification of energy intake, however, demonstrated a significantly larger ratio of obese subjects to non-obese subjects in the group with the polymorphism in the highest 4th quartile alone. Multiple logistic regression analysis also revealed that the presence of the polymorphism increased the risk of obesity significantly in the 4th quartile alone (adjusted odds ratio=3.37, 95{\%} confidence interval=1.12-10.2). Conclusion: Presence of the polymorphism alone does not significantly increase the risk of obesity. However, high energy intake interacts with the polymorphism and leads to a significant increase in risk of obesity. The Trp64Arg polymorphism of ADRB3 warrants consideration, along with other polymorphisms involved in the development of obesity, for tailor-made prevention of obesity.",
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