Increased serum and hepatic tissue levels of interleukin-18 in patients with fulminant hepatic failure

Masahiro Shinoda, Go Wakabayashi, Motohide Shimazu, Hidetsugu Saito, Ken Hoshino, Minoru Tanabe, Yasuhide Morikawa, Shigeatsu Endo, Hiromasa Ishii, Masaki Kitajima

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Fulminant hepatic failure is a serious clinical condition associated with a high mortality rate. Interleukin (IL)-18 is a pro-inflammatory cytokine that is associated with several inflammatory diseases. The purpose of the present paper was therefore to investigate whether IL-18 is elevated in patients with fulminant hepatic failure. Methods: Serum levels of IL-18 were measured in patients with fulminant hepatic failure before and after liver transplantation. Native liver tissue samples were collected and the tissue levels of IL-18 were determined. Liver tissues were stained immunohistochemically with antihuman IL-18 antibody. The serum levels of IL-1β, IL-6, IL-8, IL-12, interferon-γ, and tumor necrosis factor-α were also determined in patients with fulminant hepatic failure before and after liver transplantation. Results: Elevated levels of IL-18 in serum and hepatic tissue were observed in patients with fulminant hepatic failure. Native liver tissue samples were immunohistochemicaly positive for IL-18. Interleukin-18 levels were markedly reduced after liver replacement. No other inflammatory cytokines were substantially elevated in patients with fulminant hepatic failure. Conclusion: The serum levels of IL-18 levels are elevated much more than those of other cytokines in patients with fulminant hepatic failure.

Original languageEnglish
Pages (from-to)1731-1736
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume21
Issue number11
DOIs
Publication statusPublished - 2006

Fingerprint

Interleukin-18
Acute Liver Failure
Liver
Serum
Cytokines
Liver Transplantation
Interleukin-12
Interleukin-8
Interleukin-1
Interferons
Interleukin-6
Tumor Necrosis Factor-alpha
Mortality
Antibodies

Keywords

  • Fulminant hepatic failure
  • Inflammatory cytokines
  • Interleukin-18
  • Liver transplantation

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Increased serum and hepatic tissue levels of interleukin-18 in patients with fulminant hepatic failure. / Shinoda, Masahiro; Wakabayashi, Go; Shimazu, Motohide; Saito, Hidetsugu; Hoshino, Ken; Tanabe, Minoru; Morikawa, Yasuhide; Endo, Shigeatsu; Ishii, Hiromasa; Kitajima, Masaki.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 21, No. 11, 2006, p. 1731-1736.

Research output: Contribution to journalArticle

Shinoda, Masahiro ; Wakabayashi, Go ; Shimazu, Motohide ; Saito, Hidetsugu ; Hoshino, Ken ; Tanabe, Minoru ; Morikawa, Yasuhide ; Endo, Shigeatsu ; Ishii, Hiromasa ; Kitajima, Masaki. / Increased serum and hepatic tissue levels of interleukin-18 in patients with fulminant hepatic failure. In: Journal of Gastroenterology and Hepatology (Australia). 2006 ; Vol. 21, No. 11. pp. 1731-1736.
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T1 - Increased serum and hepatic tissue levels of interleukin-18 in patients with fulminant hepatic failure

AU - Shinoda, Masahiro

AU - Wakabayashi, Go

AU - Shimazu, Motohide

AU - Saito, Hidetsugu

AU - Hoshino, Ken

AU - Tanabe, Minoru

AU - Morikawa, Yasuhide

AU - Endo, Shigeatsu

AU - Ishii, Hiromasa

AU - Kitajima, Masaki

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AB - Background: Fulminant hepatic failure is a serious clinical condition associated with a high mortality rate. Interleukin (IL)-18 is a pro-inflammatory cytokine that is associated with several inflammatory diseases. The purpose of the present paper was therefore to investigate whether IL-18 is elevated in patients with fulminant hepatic failure. Methods: Serum levels of IL-18 were measured in patients with fulminant hepatic failure before and after liver transplantation. Native liver tissue samples were collected and the tissue levels of IL-18 were determined. Liver tissues were stained immunohistochemically with antihuman IL-18 antibody. The serum levels of IL-1β, IL-6, IL-8, IL-12, interferon-γ, and tumor necrosis factor-α were also determined in patients with fulminant hepatic failure before and after liver transplantation. Results: Elevated levels of IL-18 in serum and hepatic tissue were observed in patients with fulminant hepatic failure. Native liver tissue samples were immunohistochemicaly positive for IL-18. Interleukin-18 levels were markedly reduced after liver replacement. No other inflammatory cytokines were substantially elevated in patients with fulminant hepatic failure. Conclusion: The serum levels of IL-18 levels are elevated much more than those of other cytokines in patients with fulminant hepatic failure.

KW - Fulminant hepatic failure

KW - Inflammatory cytokines

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KW - Liver transplantation

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