Increased serum and hepatic tissue levels of interleukin-18 in patients with fulminant hepatic failure

Masahiro Shinoda, Go Wakabayashi, Motohide Shimazu, Hidetsugu Saito, Ken Hoshino, Minoru Tanabe, Yasuhide Morikawa, Shigeatsu Endo, Hiromasa Ishii, Masaki Kitajima

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16 Citations (Scopus)

Abstract

Background: Fulminant hepatic failure is a serious clinical condition associated with a high mortality rate. Interleukin (IL)-18 is a pro-inflammatory cytokine that is associated with several inflammatory diseases. The purpose of the present paper was therefore to investigate whether IL-18 is elevated in patients with fulminant hepatic failure. Methods: Serum levels of IL-18 were measured in patients with fulminant hepatic failure before and after liver transplantation. Native liver tissue samples were collected and the tissue levels of IL-18 were determined. Liver tissues were stained immunohistochemically with antihuman IL-18 antibody. The serum levels of IL-1β, IL-6, IL-8, IL-12, interferon-γ, and tumor necrosis factor-α were also determined in patients with fulminant hepatic failure before and after liver transplantation. Results: Elevated levels of IL-18 in serum and hepatic tissue were observed in patients with fulminant hepatic failure. Native liver tissue samples were immunohistochemicaly positive for IL-18. Interleukin-18 levels were markedly reduced after liver replacement. No other inflammatory cytokines were substantially elevated in patients with fulminant hepatic failure. Conclusion: The serum levels of IL-18 levels are elevated much more than those of other cytokines in patients with fulminant hepatic failure.

Original languageEnglish
Pages (from-to)1731-1736
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume21
Issue number11
DOIs
Publication statusPublished - 2006 Nov

Keywords

  • Fulminant hepatic failure
  • Inflammatory cytokines
  • Interleukin-18
  • Liver transplantation

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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    Shinoda, M., Wakabayashi, G., Shimazu, M., Saito, H., Hoshino, K., Tanabe, M., Morikawa, Y., Endo, S., Ishii, H., & Kitajima, M. (2006). Increased serum and hepatic tissue levels of interleukin-18 in patients with fulminant hepatic failure. Journal of Gastroenterology and Hepatology (Australia), 21(11), 1731-1736. https://doi.org/10.1111/j.1440-1746.2006.04376.x