Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

Aki Yamashita, Kei Kawana, Kensuke Tomio, Ayumi Taguchi, Yosuke Isobe, Ryo Iwamoto, Koji Masuda, Hitomi Furuya, Takeshi Nagamatsu, Kazunori Nagasaka, Takahide Arimoto, Katsutoshi Oda, Osamu Wada-Hiraike, Takahiro Yamashita, Yuji Taketani, Jing X. Kang, Shiro Kozuma, Hiroyuki Arai, Makoto Arita, Yutaka OsugaTomoyuki Fujii

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1β in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18- hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.

Original languageEnglish
Article number3113
JournalScientific Reports
Volume3
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint

Premature Birth
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Eicosapentaenoic Acid
Fats
Anti-Inflammatory Agents
Metabolomics
Incidence
Interleukin-1
Obstetrics
Uterus
Interleukin-6
Macrophages
Inflammation
Lipids
Gene Expression
17,18-dihydroxyeicosapentaenoic acid
Therapeutics

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Yamashita, A., Kawana, K., Tomio, K., Taguchi, A., Isobe, Y., Iwamoto, R., ... Fujii, T. (2013). Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth. Scientific Reports, 3, [3113]. https://doi.org/10.1038/srep03113

Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth. / Yamashita, Aki; Kawana, Kei; Tomio, Kensuke; Taguchi, Ayumi; Isobe, Yosuke; Iwamoto, Ryo; Masuda, Koji; Furuya, Hitomi; Nagamatsu, Takeshi; Nagasaka, Kazunori; Arimoto, Takahide; Oda, Katsutoshi; Wada-Hiraike, Osamu; Yamashita, Takahiro; Taketani, Yuji; Kang, Jing X.; Kozuma, Shiro; Arai, Hiroyuki; Arita, Makoto; Osuga, Yutaka; Fujii, Tomoyuki.

In: Scientific Reports, Vol. 3, 3113, 2013.

Research output: Contribution to journalArticle

Yamashita, A, Kawana, K, Tomio, K, Taguchi, A, Isobe, Y, Iwamoto, R, Masuda, K, Furuya, H, Nagamatsu, T, Nagasaka, K, Arimoto, T, Oda, K, Wada-Hiraike, O, Yamashita, T, Taketani, Y, Kang, JX, Kozuma, S, Arai, H, Arita, M, Osuga, Y & Fujii, T 2013, 'Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth', Scientific Reports, vol. 3, 3113. https://doi.org/10.1038/srep03113
Yamashita, Aki ; Kawana, Kei ; Tomio, Kensuke ; Taguchi, Ayumi ; Isobe, Yosuke ; Iwamoto, Ryo ; Masuda, Koji ; Furuya, Hitomi ; Nagamatsu, Takeshi ; Nagasaka, Kazunori ; Arimoto, Takahide ; Oda, Katsutoshi ; Wada-Hiraike, Osamu ; Yamashita, Takahiro ; Taketani, Yuji ; Kang, Jing X. ; Kozuma, Shiro ; Arai, Hiroyuki ; Arita, Makoto ; Osuga, Yutaka ; Fujii, Tomoyuki. / Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth. In: Scientific Reports. 2013 ; Vol. 3.
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