Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

Aki Yamashita; Kei Kawana; Kensuke Tomio; Ayumi Taguchi; Yosuke Isobe; Ryo Iwamoto; Koji Masuda; Hitomi Furuya; Takeshi Nagamatsu; Kazunori Nagasaka; Takahide Arimoto; Katsutoshi Oda; Osamu Wada-Hiraike; Takahiro Yamashita; Yuji Taketani; Jing X. Kang; Shiro Kozuma; Hiroyuki Arai; Makoto Arita; Yutaka Osuga; Tomoyuki Fujii

doi:10.1038/srep03113

Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

Aki Yamashita, Kei Kawana, Kensuke Tomio, Ayumi Taguchi, Yosuke Isobe, Ryo Iwamoto, Koji Masuda, Hitomi Furuya, Takeshi Nagamatsu, Kazunori Nagasaka, Takahide Arimoto, Katsutoshi Oda, Osamu Wada-Hiraike, Takahiro Yamashita, Yuji Taketani, Jing X. Kang, Shiro Kozuma, Hiroyuki Arai, Makoto Arita, Yutaka OsugaTomoyuki Fujii

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42 Citations (Scopus)

Abstract

Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1β in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18- hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.

Original language	English
Article number	3113
Journal	Scientific reports
Volume	3
DOIs	https://doi.org/10.1038/srep03113
Publication status	Published - 2013
Externally published	Yes

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Yamashita, A., Kawana, K., Tomio, K., Taguchi, A., Isobe, Y., Iwamoto, R., Masuda, K., Furuya, H., Nagamatsu, T., Nagasaka, K., Arimoto, T., Oda, K., Wada-Hiraike, O., Yamashita, T., Taketani, Y., Kang, J. X., Kozuma, S., Arai, H., Arita, M., ... Fujii, T. (2013). Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth. Scientific reports, 3, [3113]. https://doi.org/10.1038/srep03113

Yamashita, A, Kawana, K, Tomio, K, Taguchi, A, Isobe, Y, Iwamoto, R, Masuda, K, Furuya, H, Nagamatsu, T, Nagasaka, K, Arimoto, T, Oda, K, Wada-Hiraike, O, Yamashita, T, Taketani, Y, Kang, JX, Kozuma, S, Arai, H, Arita, M, Osuga, Y & Fujii, T 2013, 'Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth', Scientific reports, vol. 3, 3113. https://doi.org/10.1038/srep03113

@article{7787d3fac98d409682d91a248592db80,

title = "Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth",

abstract = "Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1β in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18- hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.",

author = "Aki Yamashita and Kei Kawana and Kensuke Tomio and Ayumi Taguchi and Yosuke Isobe and Ryo Iwamoto and Koji Masuda and Hitomi Furuya and Takeshi Nagamatsu and Kazunori Nagasaka and Takahide Arimoto and Katsutoshi Oda and Osamu Wada-Hiraike and Takahiro Yamashita and Yuji Taketani and Kang, {Jing X.} and Shiro Kozuma and Hiroyuki Arai and Makoto Arita and Yutaka Osuga and Tomoyuki Fujii",

note = "Funding Information: We gratefully thank Dr. Danny J. Schust for careful editing of the manuscript, Dr. Terufumi Yokoyama for excellent comments and advice on experiments using murine models and Ms. Michiko Kamio for technical assistance on LC-MS/MS analyses. This work was supported by a grant-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (K.K., T. F.), by a grant-in-aid from the Tokyo IGAKUKAI (K.K.), by grant-in-aid from Japan Science and Technology agency Precursory Research for Embryonic Science and Technology (PRESTO) (M.A.), and by grant in aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (M.A.)",

year = "2013",

doi = "10.1038/srep03113",

language = "English",

volume = "3",

journal = "Scientific Reports",

issn = "2045-2322",

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T1 - Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

AU - Yamashita, Aki

AU - Kawana, Kei

AU - Tomio, Kensuke

AU - Taguchi, Ayumi

AU - Isobe, Yosuke

AU - Iwamoto, Ryo

AU - Masuda, Koji

AU - Furuya, Hitomi

AU - Nagamatsu, Takeshi

AU - Nagasaka, Kazunori

AU - Arimoto, Takahide

AU - Oda, Katsutoshi

AU - Wada-Hiraike, Osamu

AU - Yamashita, Takahiro

AU - Taketani, Yuji

AU - Kang, Jing X.

AU - Kozuma, Shiro

AU - Arai, Hiroyuki

AU - Arita, Makoto

AU - Osuga, Yutaka

AU - Fujii, Tomoyuki

N1 - Funding Information: We gratefully thank Dr. Danny J. Schust for careful editing of the manuscript, Dr. Terufumi Yokoyama for excellent comments and advice on experiments using murine models and Ms. Michiko Kamio for technical assistance on LC-MS/MS analyses. This work was supported by a grant-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (K.K., T. F.), by a grant-in-aid from the Tokyo IGAKUKAI (K.K.), by grant-in-aid from Japan Science and Technology agency Precursory Research for Embryonic Science and Technology (PRESTO) (M.A.), and by grant in aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (M.A.)

PY - 2013

Y1 - 2013

N2 - Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1β in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18- hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.

AB - Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1β in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18- hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.

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VL - 3

JO - Scientific Reports

JF - Scientific Reports

M1 - 3113

ER -

Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth

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