Increased urinary dopamine excretion in Young patients with essential hypertension

I. Saito, S. Itsuji, E. Takeshita, H. Kawabe, M. Nishino, H. Wainai, C. Hasegawa, T. Saruta, S. Nagano, T. Sekihara

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Abstract

The evidence that some older patients with essential hypertension have low urinary dopamine excretion has brought into question the levels of urinary dopamine and plasma dopa, the major source of urinary dopamine, in young patients with essential hypertension. Twentyfour-hour urine sodium, creatinine, dopamine and noradrenaline and plasma dopa were evaluated in 48 patients with essential hypertension aged 18 to 27 years and 25 normotensive subjects. In comparison with age-matched normotensive subjects, the hypertensive patients had higher urinary dopamine (1920 ± 80 vs 1520 ± 130 nmol/day, p < 0.01) and noradrenaline (216 ± 11 vs 179 ± 12 nmol/day, p < 0.05) excretion. There was a significant correlation between urinary dopamine and noradrenaline excretion. There was no difference in plasma dopa levels between normotensive and hypertensive subjects. These results suggest that the elevated conversion of dopa to dopamine in the kidney is leading to increased urinary dopamine excretion in young patients with essential hypertension.

Original languageEnglish
Pages (from-to)29-39
Number of pages11
JournalClinical and Experimental Hypertension
Volume16
Issue number1
DOIs
Publication statusPublished - 1994 Jan 1

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Keywords

  • Dopa
  • Dopamine
  • Essential Hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Saito, I., Itsuji, S., Takeshita, E., Kawabe, H., Nishino, M., Wainai, H., Hasegawa, C., Saruta, T., Nagano, S., & Sekihara, T. (1994). Increased urinary dopamine excretion in Young patients with essential hypertension. Clinical and Experimental Hypertension, 16(1), 29-39. https://doi.org/10.3109/10641969409068582