@article{6b20ce0a02d64f5f925b7b62bc19f1d9,
title = "Increasing light physical activity helps to maintain cognitive function among the community-dwelling oldest old population: a cross-sectional study using actigraph from the Arakawa 85+ study",
abstract = "Aim: To investigate the influence of replacing sedentary time with physical activity on cognitive function using an isotemporal substitution model in a population of community-dwelling oldest old. Methods: This cross-sectional study included residents of the Arakawa ward, Tokyo, who were part of a prospective cohort from the Arakawa 85+ study. We measured physical activity in 136 participants using a triaxial actigraph. Cognitive function was measured using the Addenbrooke's Cognitive Examination-III and participants were divided into a “cognitive decline group” (Addenbrooke's Cognitive Examination-III ≤88) and “cognitive maintain group” (Addenbrooke's Cognitive Examination-III ≥89). Physical activity was divided into three categories: sedentary behavior (≤1.5 metabolic equivalents), light physical activity (>1.5 to <3.0 metabolic equivalents), and moderate-to-vigorous physical activity (≥3 metabolic equivalents). Using an isotemporal substitution approach, we applied multiple logistic regression analysis to demonstrate the association between cognitive function and replacing 30 min/day of sedentary behavior with an equal period of light physical activity. Covariates included age, education and the Center for Epidemiologic Studies Depression Scale. Results: Our findings showed that in men, replacing 30 min of sedentary behavior per day with light physical activity was associated with a 1.47-fold increase in the odds of maintaining cognitive function. An association between physical activity and cognitive function was not observed in female participants. Conclusions: Our results indicate that substituting sedentary behavior with light physical activity could be helpful in maintaining cognitive function in community-dwelling oldest old men. These results highlight the importance of behavioral changes to promote cognition. Geriatr Gerontol Int 2020; 20: 773–778.",
keywords = "actigraph, cognitive function, isotemporal substitution model, oldest old, physical activity",
author = "Kouta Suzuki and Hidehito Niimura and Hisashi Kida and Yoko Eguchi and Chiho Kitashima and Midori Takayama and Masaru Mimura",
note = "Funding Information: HN received honoraria for lectures from Sumitomo Dainippon Pharma, Mochida Pharmaceutical, Otsuka Pharmaceutical, and Mitsubishi Tanabe Pharma. MM received grants and/or speaker's honoraria from Asahi Kasei Pharma, Astellas Pharma, Daiichi Sankyo, Sumitomo Dainippon Pharma, Eisai, Eli Lilly, Fuji Film RI Pharma, Janssen Pharmaceutical, Kracie, Meiji‐Seika Pharma, Mochida Pharmaceutical, Merck Sharp and Dohme, Novartis Pharma, Ono Pharmaceutical, Otsuka Pharmaceutical, Pfizer, Shionogi, Takeda Pharmaceutical, Mitsubishi Tanabe Pharma, and Yoshitomi Yakuhin. All other authors declare that they have no conflicts of interest. HN has received research support from the Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science, Daiwa Securities Health Foundation, Univers Foundation, Taiyo Welfare Foundation, and grants or speaker's honoraria from Dainippon‐Sumitomo Pharma, Mochida Pharmaceutical, Otsuka Pharmaceutical and Tanabe Mitsubishi Pharma within the past 3 years. YE has received grants from Mitsubishi Foundation and Daiwa Securities Health Foundation within 3 years. MT has received research support from the Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science within the past 4 years. MM has received grants and/or speaker's honoraria from Asahi Kasei Pharma, Astellas Pharmaceutical, Daiichi Sankyo, Dainippon‐Sumitomo Pharma, Eisai, Eli Lilly, Fuji Film RI Pharma, Janssen Pharmaceutical, Kracie, Meiji‐Seika Pharma, Mochida Pharmaceutical, MSD, Novartis Pharma, Ono Yakuhin, Otsuka Pharmaceutical, Pfizer, Shionogi, Takeda Yakuhin, Tanabe Mitsubishi Pharma, and Yoshitomi Yakuhin, and research funding from Nishikawa Sangyo, Otsuka Pharmaceutical, MSD, Meiji‐Seika Pharma, and Shionogi & Cc., Ltd. within the past 3 years. Funding Information: We thank the participants and their families for their time and assistance, We also thank: Taiichirou Nishikawa, the Mayor of Arakawa City; Takashi Kataoka, Director of Welfare Division; Chie Tanii and Yumiko Hori, Director of the Welfare for the Elderly Section; Hiroto Mizuno, Yuichi Ozawa and Shunichi Kojima, staff members of the Welfare for the Elderly Section (sampling/analyzing basic resident registry data); Dr. Yuko Oguma, Sports Medicine Research Center, Graduate School of Health Management, Keio University; Dr. Ayano Takeuchi and Dr. Yasunori Sato, Department of Preventive Medicine and Public Health, Keio University School of Medicine; Members of the Keio University Arakawa 85+ study team: clinical psychologists Maiko Kiyohara and Ayaka Morimoto; and research secretaries Chiaki Kojima and Yukiko Miyasaka. This work was supported by Keio Research Grants for Global Initiative Research Projects (grant number SKCL000216), the Taiyo Life Welfare Foundation, the Mitsui Sumitomo Insurance Welfare Foundation and The Inokashira Hospital Grants for Psychiatry Research (grant number IHGPR2018-04). Funding Information: We thank the participants and their families for their time and assistance, We also thank: Taiichirou Nishikawa, the Mayor of Arakawa City; Takashi Kataoka, Director of Welfare Division; Chie Tanii and Yumiko Hori, Director of the Welfare for the Elderly Section; Hiroto Mizuno, Yuichi Ozawa and Shunichi Kojima, staff members of the Welfare for the Elderly Section (sampling/analyzing basic resident registry data); Dr. Yuko Oguma, Sports Medicine Research Center, Graduate School of Health Management, Keio University; Dr. Ayano Takeuchi and Dr. Yasunori Sato, Department of Preventive Medicine and Public Health, Keio University School of Medicine; Members of the Keio University Arakawa 85+ study team: clinical psychologists Maiko Kiyohara and Ayaka Morimoto; and research secretaries Chiaki Kojima and Yukiko Miyasaka. This work was supported by Keio Research Grants for Global Initiative Research Projects (grant number SKCL000216), the Taiyo Life Welfare Foundation, the Mitsui Sumitomo Insurance Welfare Foundation and The Inokashira Hospital Grants for Psychiatry Research (grant number IHGPR2018‐04). Publisher Copyright: {\textcopyright} 2020 Japan Geriatrics Society",
year = "2020",
month = aug,
day = "1",
doi = "10.1111/ggi.13967",
language = "English",
volume = "20",
pages = "773--778",
journal = "Geriatrics and Gerontology International",
issn = "1447-0594",
publisher = "Japan Geriatrics Society",
number = "8",
}