Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles

Emi Yamano, Masahiro Sugimoto, Akiyoshi Hirayama, Satoshi Kume, Masanori Yamato, Guanghua Jin, Seiki Tajima, Nobuhito Goda, Kazuhiro Iwai, Sanae Fukuda, Kouzi Yamaguti, Hirohiko Kuratsune, Tomoyoshi Soga, Yasuyoshi Watanabe, Yosky Kataoka

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Chronic fatigue syndrome (CFS) is a persistent and unexplained pathological state characterized by exertional and severely debilitating fatigue, with/without infectious or neuropsychiatric symptoms, lasting at least 6 consecutive months. Its pathogenesis remains incompletely understood. Here, we performed comprehensive metabolomic analyses of 133 plasma samples obtained from CFS patients and healthy controls to establish an objective diagnosis of CFS. CFS patients exhibited significant differences in intermediate metabolite concentrations in the tricarboxylic acid (TCA) and urea cycles. The combination of ornithine/citrulline and pyruvate/isocitrate ratios discriminated CFS patients from healthy controls, yielding area under the receiver operating characteristic curve values of 0.801 (95% confidential interval [CI]: 0.711-0.890, P < 0.0001) and 0.750 (95% CI: 0.584-0.916, P = 0.0069) for training (n = 93) and validation (n = 40) datasets, respectively. These findings provide compelling evidence that a clinical diagnostic tool could be developed for CFS based on the ratios of metabolites in plasma.

Original languageEnglish
Article number34990
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016 Oct 11

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Chronic Fatigue Syndrome
Citric Acid Cycle
Urea
Citrulline
Ornithine
Metabolomics
Pyruvic Acid
ROC Curve
Fatigue

ASJC Scopus subject areas

  • General

Cite this

Yamano, E., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., ... Kataoka, Y. (2016). Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles. Scientific Reports, 6, [34990]. https://doi.org/10.1038/srep34990

Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles. / Yamano, Emi; Sugimoto, Masahiro; Hirayama, Akiyoshi; Kume, Satoshi; Yamato, Masanori; Jin, Guanghua; Tajima, Seiki; Goda, Nobuhito; Iwai, Kazuhiro; Fukuda, Sanae; Yamaguti, Kouzi; Kuratsune, Hirohiko; Soga, Tomoyoshi; Watanabe, Yasuyoshi; Kataoka, Yosky.

In: Scientific Reports, Vol. 6, 34990, 11.10.2016.

Research output: Contribution to journalArticle

Yamano, E, Sugimoto, M, Hirayama, A, Kume, S, Yamato, M, Jin, G, Tajima, S, Goda, N, Iwai, K, Fukuda, S, Yamaguti, K, Kuratsune, H, Soga, T, Watanabe, Y & Kataoka, Y 2016, 'Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles', Scientific Reports, vol. 6, 34990. https://doi.org/10.1038/srep34990
Yamano E, Sugimoto M, Hirayama A, Kume S, Yamato M, Jin G et al. Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles. Scientific Reports. 2016 Oct 11;6. 34990. https://doi.org/10.1038/srep34990
Yamano, Emi ; Sugimoto, Masahiro ; Hirayama, Akiyoshi ; Kume, Satoshi ; Yamato, Masanori ; Jin, Guanghua ; Tajima, Seiki ; Goda, Nobuhito ; Iwai, Kazuhiro ; Fukuda, Sanae ; Yamaguti, Kouzi ; Kuratsune, Hirohiko ; Soga, Tomoyoshi ; Watanabe, Yasuyoshi ; Kataoka, Yosky. / Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles. In: Scientific Reports. 2016 ; Vol. 6.
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