Indocyanine green fluorescence imaging in the pregnant cynomolgus macaque: Childbearing is supported by a unilateral uterine artery and vein alone?

Iori Kisu, Kouji Banno, Megumi Yanokura, Yuya Nogami, Kiyoko Umene, Kosuke Tsuji, Kenta Masuda, Arisa Ueki, Yusuke Kobayashi, Daisuke Aoki

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Purpose: Uterine blood flow is required for the maintenance of uterine viability in pregnancy and delivery, but it is unknown how many vessels are necessary for maintenance of uterine viability. The objective of this study was to examine whether unilateral uterine vessels provide sufficient nutrition in pregnancy in a cynomolgus macaque and to evaluate hemodynamics of pregnant uterus by indocyanine green (ICG) fluorescence imaging. Methods: A cynomolgus macaque with uterine blood flow maintained by the right uterine artery and vein alone was made pregnant. Hemodynamics of the uterus in the third trimester was evaluated by ICG fluorescence imaging. Results: Pregnancy was maintained with the right uterine artery and vein. An appropriate-for-date infant was delivered by Cesarean section. ICG fluorescence imaging showed that the uterine body was imaged from the right side to the center; furthermore, collateral circulation was present from the right uterine artery toward the left uterine artery, with expanded blood flow to the left uterine body. Conclusion: Pregnancy and delivery were achieved in a cynomolgus macaque with a unilateral right uterine artery and vein. Blood flow to the side without the artery was complemented by vascularization of collateral circulation to the uterine artery.

Original languageEnglish
Pages (from-to)1309-1315
Number of pages7
JournalArchives of gynecology and obstetrics
Volume288
Issue number6
DOIs
Publication statusPublished - 2013 Dec 1

Keywords

  • Cynomolgus macaque
  • Indocyanine green
  • Radical trachelectomy
  • Uterine blood flow
  • Uterus transplantation

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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