Induced Regulatory T Cells: Their Development, Stability, and Applications

Mitsuhiro Kanamori, Hiroko Nakatsukasa, Masahiro Okada, Qianjin Lu, Akihiko Yoshimura

Research output: Contribution to journalReview articlepeer-review

105 Citations (Scopus)

Abstract

Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many facets of immune systems. The transcription factor Foxp3 has been characterized as a master regulator of Tregs, and is induced during their thymic development. Foxp3+ Tregs can also be generated from naïve T cells after stimulation in the presence of TGF-β and IL-2; the resulting cells are called induced Tregs (iTregs) when generated in vitro, or peripheral Tregs (pTregs) when generated in vivo. Compared to tTregs, iTregs have been shown to be unstable, and attempts to generate stable iTregs have been made for clinical applications. We review here the current knowledge on the development of pTregs, iTregs, and their roles and applications.

Original languageEnglish
Pages (from-to)803-811
Number of pages9
JournalTrends in Immunology
Volume37
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

Keywords

  • Clostridium species
  • DNA methylation
  • regulatory T cells
  • TGF-β
  • transcription factors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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