Induced Regulatory T Cells

Their Development, Stability, and Applications

Mitsuhiro Kanamori, Hiroko Nakatsukasa, Masahiro Okada, Qianjin Lu, Akihiko Yoshimura

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many facets of immune systems. The transcription factor Foxp3 has been characterized as a master regulator of Tregs, and is induced during their thymic development. Foxp3+ Tregs can also be generated from naïve T cells after stimulation in the presence of TGF-β and IL-2; the resulting cells are called induced Tregs (iTregs) when generated in vitro, or peripheral Tregs (pTregs) when generated in vivo. Compared to tTregs, iTregs have been shown to be unstable, and attempts to generate stable iTregs have been made for clinical applications. We review here the current knowledge on the development of pTregs, iTregs, and their roles and applications.

Original languageEnglish
Pages (from-to)803-811
Number of pages9
JournalTrends in Immunology
Volume37
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

Fingerprint

Regulatory T-Lymphocytes
Interleukin-2
Immune System
Transcription Factors
T-Lymphocytes
In Vitro Techniques

Keywords

  • Clostridium species
  • DNA methylation
  • regulatory T cells
  • TGF-β
  • transcription factors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Induced Regulatory T Cells : Their Development, Stability, and Applications. / Kanamori, Mitsuhiro; Nakatsukasa, Hiroko; Okada, Masahiro; Lu, Qianjin; Yoshimura, Akihiko.

In: Trends in Immunology, Vol. 37, No. 11, 01.11.2016, p. 803-811.

Research output: Contribution to journalReview article

Kanamori, Mitsuhiro ; Nakatsukasa, Hiroko ; Okada, Masahiro ; Lu, Qianjin ; Yoshimura, Akihiko. / Induced Regulatory T Cells : Their Development, Stability, and Applications. In: Trends in Immunology. 2016 ; Vol. 37, No. 11. pp. 803-811.
@article{989c8977066b4773b33e4efce044ac12,
title = "Induced Regulatory T Cells: Their Development, Stability, and Applications",
abstract = "Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many facets of immune systems. The transcription factor Foxp3 has been characterized as a master regulator of Tregs, and is induced during their thymic development. Foxp3+ Tregs can also be generated from na{\"i}ve T cells after stimulation in the presence of TGF-β and IL-2; the resulting cells are called induced Tregs (iTregs) when generated in vitro, or peripheral Tregs (pTregs) when generated in vivo. Compared to tTregs, iTregs have been shown to be unstable, and attempts to generate stable iTregs have been made for clinical applications. We review here the current knowledge on the development of pTregs, iTregs, and their roles and applications.",
keywords = "Clostridium species, DNA methylation, regulatory T cells, TGF-β, transcription factors",
author = "Mitsuhiro Kanamori and Hiroko Nakatsukasa and Masahiro Okada and Qianjin Lu and Akihiko Yoshimura",
year = "2016",
month = "11",
day = "1",
doi = "10.1016/j.it.2016.08.012",
language = "English",
volume = "37",
pages = "803--811",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Induced Regulatory T Cells

T2 - Their Development, Stability, and Applications

AU - Kanamori, Mitsuhiro

AU - Nakatsukasa, Hiroko

AU - Okada, Masahiro

AU - Lu, Qianjin

AU - Yoshimura, Akihiko

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many facets of immune systems. The transcription factor Foxp3 has been characterized as a master regulator of Tregs, and is induced during their thymic development. Foxp3+ Tregs can also be generated from naïve T cells after stimulation in the presence of TGF-β and IL-2; the resulting cells are called induced Tregs (iTregs) when generated in vitro, or peripheral Tregs (pTregs) when generated in vivo. Compared to tTregs, iTregs have been shown to be unstable, and attempts to generate stable iTregs have been made for clinical applications. We review here the current knowledge on the development of pTregs, iTregs, and their roles and applications.

AB - Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many facets of immune systems. The transcription factor Foxp3 has been characterized as a master regulator of Tregs, and is induced during their thymic development. Foxp3+ Tregs can also be generated from naïve T cells after stimulation in the presence of TGF-β and IL-2; the resulting cells are called induced Tregs (iTregs) when generated in vitro, or peripheral Tregs (pTregs) when generated in vivo. Compared to tTregs, iTregs have been shown to be unstable, and attempts to generate stable iTregs have been made for clinical applications. We review here the current knowledge on the development of pTregs, iTregs, and their roles and applications.

KW - Clostridium species

KW - DNA methylation

KW - regulatory T cells

KW - TGF-β

KW - transcription factors

UR - http://www.scopus.com/inward/record.url?scp=84992751908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992751908&partnerID=8YFLogxK

U2 - 10.1016/j.it.2016.08.012

DO - 10.1016/j.it.2016.08.012

M3 - Review article

VL - 37

SP - 803

EP - 811

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 11

ER -