Induction mechanism of a single gene molecule

Stochastic or deterministic?

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

A new field of gene expression regulation research is emerging that has previously been overlooked. This new area is concerned with distinguishing the expression of a single gene from the averaged expression of many gene copies within the cell population. This paper reviews research focused on individual genes in inducible gene expression systems. The main experimental strategy is to measure the gene expression level of a single cell containing a single reporter gene molecule. In contrast to the commonly held belief, gene induction is found to be stochastic under certain conditions. The possible mechanisms and implications are discussed.

Original languageEnglish
Pages (from-to)341-346
Number of pages6
JournalBioEssays
Volume14
Issue number5
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Genes
Gene Expression
Molecules
gene expression
genes
Gene expression
gene induction
gene expression regulation
Gene Expression Regulation
Gene expression regulation
Reporter Genes
Research
reporter genes
cells
Population
Cells

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Induction mechanism of a single gene molecule : Stochastic or deterministic? / Ko, Minoru.

In: BioEssays, Vol. 14, No. 5, 1992, p. 341-346.

Research output: Contribution to journalArticle

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