Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.

Tetsuya Kawata, Hisao Ito, Ken Motoori, Takuya Ueda, Naoyuki Shigematsu, Yoshiya Furusawa, Marco Durante, Kerry George, Honglu Wu, Francis A. Cucinotta

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.

Original languageEnglish
JournalJournal of Radiation Research
Volume43 Suppl
Publication statusPublished - 2002 Dec
Externally publishedYes

Fingerprint

Heavy Ions
Linear Energy Transfer
chromatin
fibroblasts
Chromatin
induction
heavy ions
chromatids
Fibroblasts
ions
damage
Chromatids
iron
Iron
cell nucleus
interphase
gamma radiation
G2 Phase
plateaus
Gamma Rays

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Radiation

Cite this

Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions. / Kawata, Tetsuya; Ito, Hisao; Motoori, Ken; Ueda, Takuya; Shigematsu, Naoyuki; Furusawa, Yoshiya; Durante, Marco; George, Kerry; Wu, Honglu; Cucinotta, Francis A.

In: Journal of Radiation Research, Vol. 43 Suppl, 12.2002.

Research output: Contribution to journalArticle

Kawata, T, Ito, H, Motoori, K, Ueda, T, Shigematsu, N, Furusawa, Y, Durante, M, George, K, Wu, H & Cucinotta, FA 2002, 'Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.', Journal of Radiation Research, vol. 43 Suppl.
Kawata, Tetsuya ; Ito, Hisao ; Motoori, Ken ; Ueda, Takuya ; Shigematsu, Naoyuki ; Furusawa, Yoshiya ; Durante, Marco ; George, Kerry ; Wu, Honglu ; Cucinotta, Francis A. / Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions. In: Journal of Radiation Research. 2002 ; Vol. 43 Suppl.
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AU - Durante, Marco

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