Induction of chromosome damage by aniline and its C-hydroxylated metabolites in the root cells of Vicia faba

Nobuhiro Kanaya

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The induction of sister-chromatid exchanges (SCEs) and chromosome aberrations (CAs) by aniline hydrochloride (AH) and its C-hydroxylated metabolites, o-, m- and p-aminophenol, in the root cells of Vicia faba was examined. AH induced CAs, but not SCEs. AI1 the C-hydroxylated metabolites of aniline induced both SCEs and CAs. However, the treatment of cells with these metabolites at concentrations that did not cause significant increases in CAs resulted in significant increases in SCEs. These results seem to suggest that the substance that induced CAs in root cells treated with AH was not the C-hydroxylated metabolites of aniline.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalMutation Research Letters
Volume245
Issue number4
DOIs
Publication statusPublished - 1990 Dec

Keywords

  • Aminophenols
  • Aniline
  • Chromosome aberration
  • Sister-chromatid exchange
  • Vicia faba

ASJC Scopus subject areas

  • Medicine(all)

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