TY - JOUR
T1 - Induction of chromosome damage by aniline and its C-hydroxylated metabolites in the root cells of Vicia faba
AU - Kanaya, Nobuhiro
PY - 1990/12
Y1 - 1990/12
N2 - The induction of sister-chromatid exchanges (SCEs) and chromosome aberrations (CAs) by aniline hydrochloride (AH) and its C-hydroxylated metabolites, o-, m- and p-aminophenol, in the root cells of Vicia faba was examined. AH induced CAs, but not SCEs. AI1 the C-hydroxylated metabolites of aniline induced both SCEs and CAs. However, the treatment of cells with these metabolites at concentrations that did not cause significant increases in CAs resulted in significant increases in SCEs. These results seem to suggest that the substance that induced CAs in root cells treated with AH was not the C-hydroxylated metabolites of aniline.
AB - The induction of sister-chromatid exchanges (SCEs) and chromosome aberrations (CAs) by aniline hydrochloride (AH) and its C-hydroxylated metabolites, o-, m- and p-aminophenol, in the root cells of Vicia faba was examined. AH induced CAs, but not SCEs. AI1 the C-hydroxylated metabolites of aniline induced both SCEs and CAs. However, the treatment of cells with these metabolites at concentrations that did not cause significant increases in CAs resulted in significant increases in SCEs. These results seem to suggest that the substance that induced CAs in root cells treated with AH was not the C-hydroxylated metabolites of aniline.
KW - Aminophenols
KW - Aniline
KW - Chromosome aberration
KW - Sister-chromatid exchange
KW - Vicia faba
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U2 - 10.1016/0165-7992(90)90162-D
DO - 10.1016/0165-7992(90)90162-D
M3 - Article
C2 - 2266983
AN - SCOPUS:0025222216
SN - 0165-7992
VL - 245
SP - 311
EP - 315
JO - Mutation Research Letters
JF - Mutation Research Letters
IS - 4
ER -