Induction of colonic regulatory T cells by indigenous Clostridium species

Koji Atarashi, Takeshi Tanoue, Tatsuichiro Shima, Akemi Imaoka, Tomomi Kuwahara, Yoshika Momose, Genhong Cheng, Sho Yamasaki, Takashi Saito, Yusuke Ohba, Tadatsugu Taniguchi, Kiyoshi Takeda, Shohei Hori, Ivaylo I. Ivanov, Yoshinori Umesaki, Kikuji Itoh, Kenya Honda

Research output: Contribution to journalArticle

1731 Citations (Scopus)

Abstract

CD4+ T regulatory cells (Tregs), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, Tregs were most abundant in the colonic mucosa. The spore-forming component of indigenous intestinal microbiota, particularly clusters IV and XIVa of the genus Clostridium, promoted Treg cell accumulation. Colonization of mice by a defined mix of Clostridium strains provided an environment rich in transforming growth factor-β and affected Foxp3+ Treg number and function in the colon. Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalScience
Volume331
Issue number6015
DOIs
Publication statusPublished - 2011 Jan 21
Externally publishedYes

Fingerprint

Clostridium
Regulatory T-Lymphocytes
Transforming Growth Factors
Colitis
Spores
Autoimmunity
Immunoglobulin E
Hypersensitivity
Colon
Mucous Membrane
Homeostasis
Transcription Factors
Maintenance
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Induction of colonic regulatory T cells by indigenous Clostridium species. / Atarashi, Koji; Tanoue, Takeshi; Shima, Tatsuichiro; Imaoka, Akemi; Kuwahara, Tomomi; Momose, Yoshika; Cheng, Genhong; Yamasaki, Sho; Saito, Takashi; Ohba, Yusuke; Taniguchi, Tadatsugu; Takeda, Kiyoshi; Hori, Shohei; Ivanov, Ivaylo I.; Umesaki, Yoshinori; Itoh, Kikuji; Honda, Kenya.

In: Science, Vol. 331, No. 6015, 21.01.2011, p. 337-341.

Research output: Contribution to journalArticle

Atarashi, K, Tanoue, T, Shima, T, Imaoka, A, Kuwahara, T, Momose, Y, Cheng, G, Yamasaki, S, Saito, T, Ohba, Y, Taniguchi, T, Takeda, K, Hori, S, Ivanov, II, Umesaki, Y, Itoh, K & Honda, K 2011, 'Induction of colonic regulatory T cells by indigenous Clostridium species', Science, vol. 331, no. 6015, pp. 337-341. https://doi.org/10.1126/science.1198469
Atarashi, Koji ; Tanoue, Takeshi ; Shima, Tatsuichiro ; Imaoka, Akemi ; Kuwahara, Tomomi ; Momose, Yoshika ; Cheng, Genhong ; Yamasaki, Sho ; Saito, Takashi ; Ohba, Yusuke ; Taniguchi, Tadatsugu ; Takeda, Kiyoshi ; Hori, Shohei ; Ivanov, Ivaylo I. ; Umesaki, Yoshinori ; Itoh, Kikuji ; Honda, Kenya. / Induction of colonic regulatory T cells by indigenous Clostridium species. In: Science. 2011 ; Vol. 331, No. 6015. pp. 337-341.
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