Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli

T. Mizushima, M. Matsuo, K. Sekimizu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for the induction are similar to those required for DNA relaxation and much higher than those required for cell death.

Original languageEnglish
Pages (from-to)193-195
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume41
Issue number1
Publication statusPublished - 1997
Externally publishedYes

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Chaperonin 60
Fluoroquinolones
Heat-Shock Proteins
Enoxacin
Escherichia coli
Norfloxacin
Levofloxacin
Ofloxacin
DNA
Cell Death
sparfloxacin

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli. / Mizushima, T.; Matsuo, M.; Sekimizu, K.

In: Antimicrobial Agents and Chemotherapy, Vol. 41, No. 1, 1997, p. 193-195.

Research output: Contribution to journalArticle

Mizushima, T. ; Matsuo, M. ; Sekimizu, K. / Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli. In: Antimicrobial Agents and Chemotherapy. 1997 ; Vol. 41, No. 1. pp. 193-195.
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