Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli

T. Mizushima, M. Matsuo, K. Sekimizu

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Abstract

Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for the induction are similar to those required for DNA relaxation and much higher than those required for cell death.

Original languageEnglish
Pages (from-to)193-195
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume41
Issue number1
Publication statusPublished - 1997 Jan 7

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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