Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivaylo I. Ivanov, Koji Atarashi, Nicolas Manel, Eoin L. Brodie, Tatsuichiro Shima, Ulas Karaoz, Dongguang Wei, Katherine C. Goldfarb, Clark A. Santee, Susan V. Lynch, Takeshi Tanoue, Akemi Imaoka, Kikuji Itoh, Kiyoshi Takeda, Yoshinori Umesaki, Kenya Honda, Dan R. Littman

Research output: Contribution to journalArticle

2117 Citations (Scopus)

Abstract

The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiota influence the host immune system is poorly understood. We show here that colonization of the small intestine of mice with a single commensal microbe, segmented filamentous bacterium (SFB), is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria. SFB adhere tightly to the surface of epithelial cells in the terminal ileum of mice with Th17 cells but are absent from mice that have few Th17 cells. Colonization with SFB was correlated with increased expression of genes associated with inflammation and antimicrobial defenses and resulted in enhanced resistance to the intestinal pathogen Citrobacter rodentium. Thus, manipulation of this commensal-regulated pathway may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease.

Original languageEnglish
Pages (from-to)485-498
Number of pages14
JournalCell
Volume139
Issue number3
DOIs
Publication statusPublished - 2009 Oct 30
Externally publishedYes

Fingerprint

Th17 Cells
Bacteria
Citrobacter rodentium
Mucosal Immunity
Mammals
Interleukin-17
Immune system
Microbiota
Pathogens
Helper-Inducer T-Lymphocytes
Ileum
Microorganisms
Autoimmune Diseases
Small Intestine
Gastrointestinal Tract
Immune System
Mucous Membrane
Genes
Epithelial Cells
Inflammation

Keywords

  • CELLIMMUNO
  • HUMDISEASE
  • MICROBIO

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., ... Littman, D. R. (2009). Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria. Cell, 139(3), 485-498. https://doi.org/10.1016/j.cell.2009.09.033

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria. / Ivanov, Ivaylo I.; Atarashi, Koji; Manel, Nicolas; Brodie, Eoin L.; Shima, Tatsuichiro; Karaoz, Ulas; Wei, Dongguang; Goldfarb, Katherine C.; Santee, Clark A.; Lynch, Susan V.; Tanoue, Takeshi; Imaoka, Akemi; Itoh, Kikuji; Takeda, Kiyoshi; Umesaki, Yoshinori; Honda, Kenya; Littman, Dan R.

In: Cell, Vol. 139, No. 3, 30.10.2009, p. 485-498.

Research output: Contribution to journalArticle

Ivanov, II, Atarashi, K, Manel, N, Brodie, EL, Shima, T, Karaoz, U, Wei, D, Goldfarb, KC, Santee, CA, Lynch, SV, Tanoue, T, Imaoka, A, Itoh, K, Takeda, K, Umesaki, Y, Honda, K & Littman, DR 2009, 'Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria', Cell, vol. 139, no. 3, pp. 485-498. https://doi.org/10.1016/j.cell.2009.09.033
Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U et al. Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria. Cell. 2009 Oct 30;139(3):485-498. https://doi.org/10.1016/j.cell.2009.09.033
Ivanov, Ivaylo I. ; Atarashi, Koji ; Manel, Nicolas ; Brodie, Eoin L. ; Shima, Tatsuichiro ; Karaoz, Ulas ; Wei, Dongguang ; Goldfarb, Katherine C. ; Santee, Clark A. ; Lynch, Susan V. ; Tanoue, Takeshi ; Imaoka, Akemi ; Itoh, Kikuji ; Takeda, Kiyoshi ; Umesaki, Yoshinori ; Honda, Kenya ; Littman, Dan R. / Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria. In: Cell. 2009 ; Vol. 139, No. 3. pp. 485-498.
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