Induction of morphological change by tyrosine kinase inhibitors in Rous sarcoma virus-transformed rat kidney cells

Kazuo Umezawa, Karo Tanaka, Takashi Hori, Satoko Abe, Ryuichi Sekizawa, Masaya Imoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Erbstatin and methyl 2,5-dihydroxycinnamate, related tyrosine kinase inhibitors, induced a morphological change in temperature-sensitive Rous sarcoma virus-transformed rat kidney (RSV15·NRK) that brought the cells close to the morphology of their normal counterpart. Erbstatin did not change the morphology of normal or Kirsten sarcoma virus-transformed rat kidney cells. Erbstatin also inhibited morphological transformation of RSV15·NRK cells induced by a shifting in temperature. Actin stress fibres were observed only in normal cells and not in transformed cells. Erbstatin induced stress fibre organization in transformed cells. Erbstatin and methyl 2.5-dihydroxycinnamate increased fibronectin gene expression in RSV-transformed cells. Thus, tyrosine kinase inhibitors induced normal phenotypes specifically in v-sre-expressing cells.

Original languageEnglish
Pages (from-to)132-136
Number of pages5
JournalFEBS Letters
Volume279
Issue number1
DOIs
Publication statusPublished - 1991 Feb 11

Keywords

  • Cytoskeleton
  • Erbstatin
  • Fibronectin
  • Morphology
  • Sre
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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