Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia

Tomonori Hiramatsu; Masaya Imoto; Takashi Koyano; Kazuo Umezawa

doi:10.1016/0304-3835(93)90259-C

Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia

Tomonori Hiramatsu, Masaya Imoto, Takashi Koyano, Kazuo Umezawa

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

We have screened tropical plant extracts for substances that induce normal morphology in K-ras^ts-NRK cells. As a result we isolated an anthraquinone compound, damnacanthal, from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal structure in K-ras^ts-NRK cells at the permissive temperature, without changing the amount and localization of Ras. The effect of damnacanthal was reversible, and the compound had no effect on the morphology of RSV^ts-NRK cells expressing the src oncogene. Thus, damnacanthal is a new inhibitor of ras function.

Original language	English
Pages (from-to)	161-166
Number of pages	6
Journal	Cancer Letters
Volume	73
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3835(93)90259-C
Publication status	Published - 1993 Sept 30
Externally published	Yes

Keywords

Damnacanthal
Morinda cirtrifolia
Ras

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(93)90259-C

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title = "Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia",

abstract = "We have screened tropical plant extracts for substances that induce normal morphology in K-rasts-NRK cells. As a result we isolated an anthraquinone compound, damnacanthal, from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal structure in K-rasts-NRK cells at the permissive temperature, without changing the amount and localization of Ras. The effect of damnacanthal was reversible, and the compound had no effect on the morphology of RSVts-NRK cells expressing the src oncogene. Thus, damnacanthal is a new inhibitor of ras function.",

keywords = "Damnacanthal, Morinda cirtrifolia, Ras",

author = "Tomonori Hiramatsu and Masaya Imoto and Takashi Koyano and Kazuo Umezawa",

note = "Funding Information: The authorsw isht o thankD r. S. Ohba, Depart-mento f ChemistryK, eio University,f or the X-ray crystallographica nalysiso f damnacanthalT. his work was partly supportedb y grants from the Ministry of Education,S cience,a nd Culture, and the Life ScienceF oundationo f Japan.",

year = "1993",

month = sep,

day = "30",

doi = "10.1016/0304-3835(93)90259-C",

language = "English",

volume = "73",

pages = "161--166",

journal = "Cancer Letters",

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number = "2-3",

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TY - JOUR

T1 - Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia

AU - Hiramatsu, Tomonori

AU - Imoto, Masaya

AU - Koyano, Takashi

AU - Umezawa, Kazuo

N1 - Funding Information: The authorsw isht o thankD r. S. Ohba, Depart-mento f ChemistryK, eio University,f or the X-ray crystallographica nalysiso f damnacanthalT. his work was partly supportedb y grants from the Ministry of Education,S cience,a nd Culture, and the Life ScienceF oundationo f Japan.

PY - 1993/9/30

Y1 - 1993/9/30

N2 - We have screened tropical plant extracts for substances that induce normal morphology in K-rasts-NRK cells. As a result we isolated an anthraquinone compound, damnacanthal, from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal structure in K-rasts-NRK cells at the permissive temperature, without changing the amount and localization of Ras. The effect of damnacanthal was reversible, and the compound had no effect on the morphology of RSVts-NRK cells expressing the src oncogene. Thus, damnacanthal is a new inhibitor of ras function.

AB - We have screened tropical plant extracts for substances that induce normal morphology in K-rasts-NRK cells. As a result we isolated an anthraquinone compound, damnacanthal, from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal structure in K-rasts-NRK cells at the permissive temperature, without changing the amount and localization of Ras. The effect of damnacanthal was reversible, and the compound had no effect on the morphology of RSVts-NRK cells expressing the src oncogene. Thus, damnacanthal is a new inhibitor of ras function.

KW - Damnacanthal

KW - Morinda cirtrifolia

KW - Ras

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DO - 10.1016/0304-3835(93)90259-C

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AN - SCOPUS:0027432850

SN - 0304-3835

VL - 73

SP - 161

EP - 166

JO - Cancer Letters

JF - Cancer Letters

IS - 2-3

ER -

Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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