Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host-microbiota homeostasis

Takeshi Tanoue; Kenya Honda

doi:10.1016/j.smim.2011.11.009

Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host-microbiota homeostasis

Takeshi Tanoue, Kenya Honda

Research output: Contribution to journal › Review article › peer-review

52 Citations (Scopus)

Abstract

CD4 ⁺ regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed that specific components of the intestinal microbiota influence the number and function of Treg cells. Substantial changes in the composition of microbiota have been associated with inflammatory bowel disease. In this review, we will discuss recent findings that associate intestinal microbiota in mice with Treg responses and with the maintenance of intestinal immune homeostasis.

Original language	English
Pages (from-to)	50-57
Number of pages	8
Journal	Seminars in Immunology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.smim.2011.11.009
Publication status	Published - 2012 Feb
Externally published	Yes

Keywords

Clostridium
Germ-free
Intestinal microbiota
Treg

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.smim.2011.11.009

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abstract = "CD4 + regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed that specific components of the intestinal microbiota influence the number and function of Treg cells. Substantial changes in the composition of microbiota have been associated with inflammatory bowel disease. In this review, we will discuss recent findings that associate intestinal microbiota in mice with Treg responses and with the maintenance of intestinal immune homeostasis.",

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AU - Tanoue, Takeshi

AU - Honda, Kenya

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AB - CD4 + regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed that specific components of the intestinal microbiota influence the number and function of Treg cells. Substantial changes in the composition of microbiota have been associated with inflammatory bowel disease. In this review, we will discuss recent findings that associate intestinal microbiota in mice with Treg responses and with the maintenance of intestinal immune homeostasis.

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Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host-microbiota homeostasis

Abstract

Keywords

ASJC Scopus subject areas

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