Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host-microbiota homeostasis

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

CD4 + regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a critical role in maintaining immunological homeostasis. Treg cells are highly abundant in the mouse intestinal lamina propria, particularly in the colon. Recent studies using germ-free and gnotobiotic mice have revealed that specific components of the intestinal microbiota influence the number and function of Treg cells. Substantial changes in the composition of microbiota have been associated with inflammatory bowel disease. In this review, we will discuss recent findings that associate intestinal microbiota in mice with Treg responses and with the maintenance of intestinal immune homeostasis.

Original languageEnglish
Pages (from-to)50-57
Number of pages8
JournalSeminars in Immunology
Volume24
Issue number1
DOIs
Publication statusPublished - 2012 Feb 1
Externally publishedYes

Keywords

  • Clostridium
  • Germ-free
  • Intestinal microbiota
  • Treg

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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