Inexplicable suppression of hepatic uptake of gallium-67, a case report

T. Nakahara, H. Fujii, K. Nakamura, J. Hashimoto, A. Kubo

Research output: Contribution to journalArticle

Abstract

We describe here a case report of a patient with acute lymphocytic leukemia in whom hepatic gallium-67 (Ga-67) uptake was suppressed. The patient was hospitalized with increasing dyspnea. In Ga-67 scintigraphy, there was no hepatic uptake, although other physiological uptake was clearly observed. In addition, the scintigraphy showed increased accumulation in the right lung consistent with infection. We considered possible reasons for these findings. The patient had no history of chemotherapy or blood transfusion, and his iron metabolism was almost normal. He was not receiving any medication which might reduce hepatic blood flow. Blood chemistry suggested normal hepatic and renal function. The patient died from pneumonia 6 weeks later. The autopsy revealed extensive infiltration of the right lung with Bacillus cereus (B. cereus). Metabolic acidosis and/or iron utilization of B. cereus may induce both increased Ga-67 accumulation in the infected lesion and suppressed uptake in the liver, but these mechanisms could not explain normal physiological uptake in the other organs. This case warranted the further study of the hepatic Ga67 uptake mechanism.

Original languageEnglish
Pages (from-to)377-379
Number of pages3
JournalAnnals of Nuclear Medicine
Volume15
Issue number4
DOIs
Publication statusPublished - 2001 Jan 1

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Keywords

  • Gallium-67 scintigraphy
  • Hepatic uptake
  • Physiological uptake

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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