Infectious complications in chronic graft-versus-host disease: A retrospective study of 145 recipients of allogeneic hematopoietic stem cell transplantation with reduced- and conventional-intensity conditioning regimens

S. Yamasaki, Y. Heike, S. Mori, T. Fukuda, D. Maruyama, R. Kato, E. Usui, K. Koido, S. Kim, R. Tanosaki, K. Tobinai, T. Teshima, Y. Takaue

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To assess infectious complications associated with chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) with reduced- and conventional-intensity conditioning regimens (RIC, n=91; CIC, n=54, respectively), we retrospectively analyzed data from 145 consecutive patients with cGVHD after allogeneic HSCT from a human leukocyte antigen-matched related or unrelated donor. In the present retrospective analysis, 57% (83/145) of patients with cGVHD developed infections, with a mortality rate of 27% (22/83). The incidences of bacteremia (n=28), central venous catheter-related infections (n=11), bacterial pneumonia (n=4), invasive aspergillosis (n=7), and adenoviral hemorrhagic cystitis (n=8) were significantly higher in patients with prednisolone dose ≥1 mg/kg at the time of diagnosis of cGVHD. The present results suggest that infections associated with cGVHD, especially after high-dose prednisolone, are predictive of poor outcome regardless of whether the patient received RIC or CIC.

Original languageEnglish
Pages (from-to)252-259
Number of pages8
JournalTransplant Infectious Disease
Volume10
Issue number4
DOIs
Publication statusPublished - 2008 Aug 1
Externally publishedYes

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Chronic graft-versus-host disease
  • HLA-matched donor
  • Infectious complication
  • Reduced-intensity conditioning

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

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