Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

Shigeru Ko, Sakiko Azuma, Yukihiro Yokoyama, Akiko Yamamoto, Kazuhiro Kyokane, Shumpei Niida, Hiroshi Ishiguro, Minoru Ko

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have recently identified the zinc finger and SCAN domain containing 4 (Zscan4), which is transiently expressed and regulates telomere elongation and genome stability in mouse embryonic stem (ES) cells. The aim of this study was to examine the expression of ZSCAN4 in the adult pancreas and elucidate the role of ZSCAN4 in tissue inflammation and subsequent regeneration. The expression of ZSCAN4 and other progenitor or differentiated cell markers in the human pancreas was immunohistochemically examined. Pancreas sections of alcoholic or autoimmune pancreatitis patients before and under maintenance corticosteroid treatment were used in this study. In the adult human pancreas a small number of ZSCAN4-positive (ZSCAN4+) cells are present among cells located in the islets of Langerhans, acini, ducts, and oval-shaped cells. These cells not only express differentiated cell markers for each compartment of the pancreas but also express other tissue stem/progenitor cell markers. Furthermore, the number of ZSCAN4+ cells dramatically increased in patients with chronic pancreatitis, especially in the pancreatic tissues of autoimmune pancreatitis actively regenerating under corticosteroid treatment. Interestingly, a number of ZSCAN4+ cells in the pancreas of autoimmune pancreatitis returned to the basal level after 1 yr of maintenance corticosteroid treatment. In conclusion, coexpression of progenitor cell markers and differentiated cell markers with ZSCAN4 in each compartment of the pancreas may indicate the presence of facultative progenitors for both exocrine and endocrine cells in the adult pancreas.

Original languageEnglish
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume304
Issue number12
DOIs
Publication statusPublished - 2013 Jun 16

Fingerprint

Pancreas
Stem Cells
Inflammation
Pancreatitis
Adrenal Cortex Hormones
Cell Count
Maintenance
Endocrine Cells
Genomic Instability
Zinc Fingers
Telomere
Chronic Pancreatitis
Islets of Langerhans
Regeneration
Therapeutics

Keywords

  • Autoimmune pancreatitis
  • Facultative progenitor cells
  • Regeneration

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology (medical)
  • Physiology
  • Hepatology

Cite this

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas. / Ko, Shigeru; Azuma, Sakiko; Yokoyama, Yukihiro; Yamamoto, Akiko; Kyokane, Kazuhiro; Niida, Shumpei; Ishiguro, Hiroshi; Ko, Minoru.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 304, No. 12, 16.06.2013.

Research output: Contribution to journalArticle

Ko, Shigeru ; Azuma, Sakiko ; Yokoyama, Yukihiro ; Yamamoto, Akiko ; Kyokane, Kazuhiro ; Niida, Shumpei ; Ishiguro, Hiroshi ; Ko, Minoru. / Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 2013 ; Vol. 304, No. 12.
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