Inflammatory bowel disease in children: Epidemiological analysis of the nationwide IBD registry in Japan

Takashi Ishige, Takeshi Tomomasa, Toru Takebayashi, Keiko Asakura, Mamoru Watanabe, Tomoko Suzuki, Reiko Miyazawa, Hirokazu Arakawa

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objective: We analyzed the database of the Japanese nationwide inflammatory bowel disease (IBD) registry, which was started in 1975, to characterize basic epidemiological and clinical features of childhood IBD, comparing them to those in adults. Study design: We analyzed the age of disease onset, disease severity and anatomical distribution in patients that were newly registered between 2003 and 2006 (n = 2,940 for CD and 14,857 for UC). We also analyzed the current age, gender and family history of IBD of all patients filed in 2005, which included patients who were newly registered in 2005 and those who had been registered before 2005 and for whom an annual report had been received in 2005 (total number of subjects: 10,934 for CD and 37,846 for UC). Results: At the time of registration, 10.6% of CD and 5.9% of UC patients were ≤16 years old. In CD, the male to female ratio was 2.6 in adult- and 1.7 in childhood-onset patients (P < 0.001). In UC, the male to female ratio was close to 1 in both age groups. In comparison with adults, pediatric patients more commonly had a positive family history for CD and UC (P < 0.001), tended to have more severe disease at the time of registry (P < 0.001 for CD, P < 0.05 for UC) and more often had extensive colitis in UC (P < 0.001). Conclusion: The nationwide registry in Japan showed IBD in children has clinical features that are distinct from those in adults.

Original languageEnglish
Pages (from-to)911-917
Number of pages7
JournalJournal of Gastroenterology
Volume45
Issue number9
DOIs
Publication statusPublished - 2010 Sep

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Inflammatory Bowel Diseases
Registries
Japan
Annual Reports
Colitis
Age of Onset
Age Groups
Databases
Pediatrics

Keywords

  • Child
  • Crohn's disease
  • Incidence
  • Montreal classification
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Inflammatory bowel disease in children : Epidemiological analysis of the nationwide IBD registry in Japan. / Ishige, Takashi; Tomomasa, Takeshi; Takebayashi, Toru; Asakura, Keiko; Watanabe, Mamoru; Suzuki, Tomoko; Miyazawa, Reiko; Arakawa, Hirokazu.

In: Journal of Gastroenterology, Vol. 45, No. 9, 09.2010, p. 911-917.

Research output: Contribution to journalArticle

Ishige, T, Tomomasa, T, Takebayashi, T, Asakura, K, Watanabe, M, Suzuki, T, Miyazawa, R & Arakawa, H 2010, 'Inflammatory bowel disease in children: Epidemiological analysis of the nationwide IBD registry in Japan', Journal of Gastroenterology, vol. 45, no. 9, pp. 911-917. https://doi.org/10.1007/s00535-010-0223-7
Ishige, Takashi ; Tomomasa, Takeshi ; Takebayashi, Toru ; Asakura, Keiko ; Watanabe, Mamoru ; Suzuki, Tomoko ; Miyazawa, Reiko ; Arakawa, Hirokazu. / Inflammatory bowel disease in children : Epidemiological analysis of the nationwide IBD registry in Japan. In: Journal of Gastroenterology. 2010 ; Vol. 45, No. 9. pp. 911-917.
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