Abstract
Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of subacute, chronic or acute systemic immune-mediated diseases of the skeletal muscles. Recently, research has shown the utility of adding new classifications of myopathies, mainly based on their pathology and the presence of specific autoantibodies. In addition, developments in genetics have helped reveal the genetic background of IIM. The human leukocyte antigen genomic region has been consistently shown to be the strongest genetic risk factor for IIM. The present review summarizes the previous and current literature on human leukocyte antigen analysis of IIM, as well as future directions for research.
| Original language | English |
|---|---|
| Journal | Clinical and Experimental Neuroimmunology |
| DOIs | |
| Publication status | Accepted/In press - 2017 |
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Keywords
- Human leukocyte antigen
- Idiopathic inflammatory myopathy
- Myositis-specific autoantibodies
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
- Immunology
- Immunology and Microbiology (miscellaneous)
- Clinical Neurology
Cite this
Inflammatory myopathies and human leukocyte antigen. / Ohnuki, Yuko; Suzuki, Shigeaki; Shiina, Takashi.
In: Clinical and Experimental Neuroimmunology, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inflammatory myopathies and human leukocyte antigen
AU - Ohnuki, Yuko
AU - Suzuki, Shigeaki
AU - Shiina, Takashi
PY - 2017
Y1 - 2017
N2 - Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of subacute, chronic or acute systemic immune-mediated diseases of the skeletal muscles. Recently, research has shown the utility of adding new classifications of myopathies, mainly based on their pathology and the presence of specific autoantibodies. In addition, developments in genetics have helped reveal the genetic background of IIM. The human leukocyte antigen genomic region has been consistently shown to be the strongest genetic risk factor for IIM. The present review summarizes the previous and current literature on human leukocyte antigen analysis of IIM, as well as future directions for research.
AB - Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of subacute, chronic or acute systemic immune-mediated diseases of the skeletal muscles. Recently, research has shown the utility of adding new classifications of myopathies, mainly based on their pathology and the presence of specific autoantibodies. In addition, developments in genetics have helped reveal the genetic background of IIM. The human leukocyte antigen genomic region has been consistently shown to be the strongest genetic risk factor for IIM. The present review summarizes the previous and current literature on human leukocyte antigen analysis of IIM, as well as future directions for research.
KW - Human leukocyte antigen
KW - Idiopathic inflammatory myopathy
KW - Myositis-specific autoantibodies
UR - http://www.scopus.com/inward/record.url?scp=85031508790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85031508790&partnerID=8YFLogxK
U2 - 10.1111/cen3.12422
DO - 10.1111/cen3.12422
M3 - Article
AN - SCOPUS:85031508790
JO - Clinical and Experimental Neuroimmunology
JF - Clinical and Experimental Neuroimmunology
SN - 1759-1961
ER -